Evidence map›Paper›PMID 36127649›Full record

ArticleBMC pulmonary medicine2022

Artificial intelligence to differentiate asthma from COPD in medico-administrative databases.

Hassan Joumaa, Raphaël Sigogne, Milka Maravic, Lucas Perray, Arnaud Bourdin, Nicolas Roche

Open access · goldAbstract read
In one paragraph

Article in BMC pulmonary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Hassan JoumaaDepartment of Respiratory Medicine, Cochin Hospital, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France. hassan.joumaa@aphp.fr.
Raphaël SigogneIQVIA, La Défense, France.
Milka MaravicIQVIA, La Défense, France.
Lucas PerrayIQVIA, La Défense, France.
Arnaud BourdinPhyMedExp, INSERM U1046, CNRS UMR 9214, University of Montpellier, Montpellier, France.
Nicolas RocheDepartment of Respiratory Medicine, Cochin Hospital, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.
IQVIA (France) · FRAssistance Publique – Hôpitaux de Paris · FRHôpital Arnaud de Villeneuve · FRHôpital Cochin · FRHôpital Lariboisière · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDiscriminating asthma from chronic obstructive pulmonary disease (COPD) using medico-administrative databases is challenging but necessary for medico-economic analyses focusing on respiratory diseases. Artificial intelligence (AI) may improve dedicated algorithms.

objectivesTo assess performance of different AI-based approaches to distinguish asthmatics from COPD patients in medico-administrative databases where the clinical diagnosis is absent. An "Asthma COPD Overlap" category was defined to further test whether AI can detect complexity.

methodsThis study included 178,962 patients treated by two "R03" treatment prescriptions at least from January 2016 to December 2018 and managed by either a general practitioner and/or a pulmonologist participating in a permanent longitudinal observatory of prescription in ambulatory medicine (LPD). Clinical diagnoses are available in this database and were used as gold standards to develop diagnostic rules. Three types of AI approaches were explored using data restricted to demographics and treatment dispensations: multinomial regression, gradient boosting and recurrent neural networks (RNN). The best performing model (based on metric properties) was then applied to estimate the size of asthma and COPD populations based on a database (LRx) of treatment dispensations between July, 2018 and June, 2019.

resultsThe best models were obtained with the boosting approach and RNN, with an overall accuracy of 68%. Performance metrics were better for asthma than COPD. Based on LRx data, the extrapolated numbers of patients treated for asthma and COPD in France were 3.7 and 1.2 million, respectively. Asthma patients were younger than COPD patients (mean, 49.9 vs. 72.1 years); COPD occurred mostly in men (68%) compared to asthma (33%).

conclusionAI can provide models with acceptable accuracy to distinguish between asthma, ACO and COPD in medico-administrative databases where the clinical diagnosis is absent. Deep learning and machine learning (RNN) had similar performances in this regard.

Indexed as

AsthmaPulmonary Disease, Chronic ObstructiveAlgorithmsArtificial IntelligenceDatabases, FactualHumansMaleAlgorithmsAsthmaChronic obstructive pulmonary diseaseCOPDEpidemiologyHealthcare administrative databasesICD codePrevalence

Identifiers

PMID36127649
PMCPMC9487098
OpenAlexW4296416927

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.