Evidence map›Paper›PMID 36127647›Full record

ArticleBMC neurology2022

Periostin and TNF-α expression levels in peripheral blood of patients with acute cerebral infarction combined with obstructive sleep apnea syndrome and their predictive value for clinical prognosis.

Yu Xin, Shuai Li, Huimin Liu, Bo Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yu XinDepartment of Neurology, The First Affiliated Hospital of Baotou Medical College, Baotou, 014010, Inner Mongolia, China.
Shuai LiDepartment of Neurology, The First Affiliated Hospital of Baotou Medical College, Baotou, 014010, Inner Mongolia, China.
Huimin LiuDepartment of Neurology, The First Affiliated Hospital of Baotou Medical College, Baotou, 014010, Inner Mongolia, China.
Bo LiuDepartment of Neurology, The First Affiliated Hospital of Baotou Medical College, Baotou, 014010, Inner Mongolia, China. liu_bo2006@126.com.
Baotou Medical College · CN

Funding

Inner Mongolia Higher Education Science and Technology Research Project NJZZ22076
6 · The paper itself

Abstract

objectiveTo detect the expression levels of periostin and tumour necrosis factor-α (TNF-α) in patients with acute cerebral infarction (ACI) combined with obstructive sleep apnea syndrome (OSAS) and to investigate their predictive value for clinical prognosis.

methodsIn this case‒control study, serum periostin and TNF-α levels were measured using ELISA, and patients were scored on the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Receiver operating characteristic curve(ROC) were generated to analyse the effect of peripheral blood periostin and TNF-α levels on poor prognosis.

resultsNIHSS score, mRS score and peripheral blood periostin and TNF-α levels were higher in the observation group than in the control group (P < 0.001); serum periostin and TNF-α levels were positively correlated with the NIHSS score and mRS score (P < 0.001). Serum periostin and TNF-α levels were higher in patients with a poor prognosis than in those with a favourable prognosis (P < 0.001); the area under curve (AUC) values for the diagnosis of poor prognosis based on TNF-α, periostin or both factors were 0.868 (95% CI: 0.781-0.954), 0.834 (95% CI: 0.734-0.934), and 0.875 (95% CI: 0.792 ~ 0.958), with sensitivities of 0.654, 0.846, and 0.654 and specificities of 0.944, 0.750, and 0.917, respectively.

conclusionPatients with ACI combined with OSAS have elevated peripheral blood periostin and TNF-α levels, and the combination of these two factors has high predictive value for poor prognosis.

Indexed as

Brain IschemiaSleep Apnea, ObstructiveStrokeAcute DiseaseCase-Control StudiesCerebral InfarctionHumansPrognosisTumor Necrosis Factor-alphaTumor Necrosis Factor-alphaAcute cerebral infarctionClinical prognosisObstructive sleep apnoea syndromePeriostinTumour necrosis factor-α

Identifiers

PMID36127647
PMCPMC9487120
OpenAlexW4296785487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.