Evidence map›Paper›PMID 36127625›Full record

ArticleTechniques in coloproctology2023

Mesorectal failure after chemoradiotherapy for squamous cell carcinoma of the anus: is sphincter-saving surgery reasonable?

T Bertrand, J F Aramburu, C Labiad, M Giacca, M Monsinjon, Y Panis

Abstract read
PubMed Publisher
In one paragraph

Article in Techniques in coloproctology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

T BertrandService de Chirurgie Colorectale, DMU DIGEST, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris (APHP), Université de Paris, 100 boulevard du Général Leclerc, 92110, Clichy, France.
J F AramburuService de Chirurgie Colorectale, DMU DIGEST, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris (APHP), Université de Paris, 100 boulevard du Général Leclerc, 92110, Clichy, France.
C LabiadService de Chirurgie Colorectale, DMU DIGEST, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris (APHP), Université de Paris, 100 boulevard du Général Leclerc, 92110, Clichy, France.
M GiaccaService de Chirurgie Colorectale, DMU DIGEST, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris (APHP), Université de Paris, 100 boulevard du Général Leclerc, 92110, Clichy, France.
M MonsinjonService de Chirurgie Colorectale, DMU DIGEST, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris (APHP), Université de Paris, 100 boulevard du Général Leclerc, 92110, Clichy, France.
Y PanisService de Chirurgie Colorectale, DMU DIGEST, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris (APHP), Université de Paris, 100 boulevard du Général Leclerc, 92110, Clichy, France. yves.panis@aphp.fr.ORCID 0000-0001-9553-9727
Hôpital Beaujon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbdominoperineal resection (APR) is today the standard treatment for improving survival in case of mesorectal failure without anal canal recurrence after chemoradiotherapy (CRT) for squamous cell carcinoma of the anus (SCC). The aim of this study was to assess if a sphincter-saving surgery is a safe alternative to classical salvage APR in these patients.

methodsA retrospective study was conducted on all patients who had total mesorectal excision (TME) with sphincter-saving surgery either with coloanal or low colorectal anastomosis, for mesorectal failure after CRT for SCC between 2012 and 2020 at our institution. The main endpoint of our study was oncological results at the end of follow-up. Postoperative morbidity and mortality were secondary endpoints.

resultsThere were 10 patients, (8 women, median age 55 years [range 45-61 years]). On TME specimens, R0 resections were noted in five (50%), R1 resection in four (40%) and R2 resection in one (10%). After a median follow-up of 42 months (4-74 months), five patients were alive, and four (40%) were alive at 5-year follow-up. During follow-up, locoregional failure after TME was noted in two patients (20%), distant relapse in three patients (30%) and both locoregional plus distant failure in two patients (20%). Only two patients (20%) had anal recurrence, one in the anal canal, the other in the peri-anastomotic area. Long- term local control was achieved in 2 of the 5 patients (40%) who underwent R0 resection versus only 1/4 patients (25%) with R1 resection.

conclusionsOur preliminary study suggested that sphincter-saving surgery could be proposed in selected patients with SCC presenting mesorectal failure after CRT, providing a feasible R0 resection.

Indexed as

Anus NeoplasmsCarcinoma, Squamous CellRectal NeoplasmsAnal CanalChemoradiotherapyFemaleHumansMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesTreatment OutcomeLocoregional failureSphincter-saving surgerySquamous cell carcinomaTotal mesorectal excision

Identifiers

PMID36127625
OpenAlexW4297874941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.