ArticleScientific reports2022
Glucocorticoid receptor activation reduces food intake independent of hyperglycemia in zebrafish.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Effects of Dietary Host-DerivedAnimals : an open access journal from MDPI · 2026Article
- Developmental and tissue-specific expression of thyrotropin-releasing hormone signaling genes in zebrafish and its association with glycemic regulation.Biology open · 2026Article
- Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish.Scientific reports · 2025Article
- Leptin and adiponectin in children and young persons with congenital adrenal hyperplasia.European journal of endocrinology · 2025Article
- Acute Stress Effects over Time on Gene Expression Patterns in the Male Zebrafish (Animals : an open access journal from MDPI · 2025Article
- Methylene blue at recommended concentrations alters metabolism in early zebrafish development.Communications biology · 2025Article
- Stable-isotope tracing reveals the role of corticosteroid receptors in driving cortisol-mediated central and peripheral glucose regulation in zebrafish.Frontiers in endocrinology · 2025Article
- Neglected function of gastrin to reduce feeding in Siberian sturgeon (Acipenser baerii) via cholecystokinin receptor B.Fish physiology and biochemistry · 2024Article
- Tiger nut/coconut dietary intervention as antidotal nutritional remediation strategy against neurobehavioural deficits following organophosphate-induced gut-brain axis dysregulation in mice.Toxicology reports · 2024Article
- Fish Responses to Alternative Feeding Ingredients under Abiotic Chronic Stress.Animals : an open access journal from MDPI · 2024Review
- Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish.Frontiers in endocrinology · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic cortisol exposure suppresses food intake in fish, but the central mechanism(s) involved in appetite regulation are unclear. Stress and the associated increase in cortisol levels increase hepatic gluconeogenesis, leading to hyperglycemia. As hyperglycemia causes a reduction in food intake, we tested the hypothesis that cortisol-induced hyperglycemia suppresses feeding in zebrafish (Danio rerio). We first established that stress-independent hyperglycemia suppressed food intake, and this corresponded with a reduction in the phosphorylation of the nutrient sensor, AMP-activated protein kinase (AMPK) in the brain. Chronic cortisol exposure also led to hyperglycemia and reduced food intake, but the mechanisms were distinct. In cortisol-exposed fish, there were no changes in brain glucose uptake or AMPK phosphorylation. Also, the phosphorylation of Akt and mTOR was reduced along with an increase in redd1, suggesting an enhanced capacity for proteolysis. Loss of the glucocorticoid receptor did not rescue cortisol-mediated feeding suppression but did increase glucose uptake and abolished the changes seen in mTOR phosphorylation and redd1 transcript abundance. Taken together, our results indicate that GR activation enhances brain proteolysis, and the associated amino acids levels, and not hyperglycemia, maybe a key mediator of the feeding suppression in response to chronic cortisol stimulation in zebrafish.
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