ArticleScientific reports2022
Rate of speech decline in individuals with amyotrophic lateral sclerosis.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- What can vowel acoustics reveal about the communicative participation of people living with ALS?Amyotrophic lateral sclerosis & frontotemporal degeneration · 2026Article
- Digital Remote Assessment of Motor and Speech Changes in Amyotrophic Lateral Sclerosis: Longitudinal Observational Study.JMIR formative research · 2026Observational
- Speech-based digital endpoints track ALS progression and align with standard clinical outcomes: evidence from the VRG50635 trial.Scientific reports · 2026Article
- Exploring the use of narrative-based approaches in individuals with amyotrophic lateral sclerosis: A narrative review.Palliative & supportive care · 2026Review
- Feasibility study on a noninvasive assessment of ALS patient emotional state.Frontiers in digital health · 2026Article
- Rehabilitation in Amyotrophic Lateral Sclerosis: Recommendations for Clinical Practice and Further Research.Journal of clinical medicine · 2025Review
- Collection and Analysis of Repeated Speech Samples: Methodological Framework and Example Protocol.JMIR research protocols · 2025Article
- Clinical assessment and interpretation of dysarthria in ALS using attention based deep learning AI models.NPJ digital medicine · 2025Article
- Listener effort measures clinically meaningful change of dysarthria in amyotrophic lateral sclerosis.Brain communications · 2025Article
- From pronounced to imagined: improving speech decoding with multi-condition EEG data.Frontiers in neuroinformatics · 2025Article
- Access for ALL in ALS: A large-scale, inclusive, collaborative consortium to unlock the molecular and genetic mechanisms of amyotrophic lateral sclerosis.Muscle & nerve · 2024Review
- Neurological complications in oncology and their monitoring and management in clinical practice: a narrative review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Review
- Multimodal speech biomarkers for remote monitoring of ALS disease progression.Computers in biology and medicine · 2024Article
- The relationship of rate and pause features to the communicative participation of people living with ALS.Muscle & nerve · 2024Article
- A Clinical Focus on Shared Decision Making in Clinical Practice When Providing Dysarthria and Dysphagia Services to Individuals With Amyotrophic Lateral Sclerosis.Perspectives of the ASHA special interest groups · 2024Article
- Multimodal Speech Biomarkers for Remote Monitoring of ALS Disease Progression.medRxiv : the preprint server for health sciences · 2024Article
- Detecting bulbar amyotrophic lateral sclerosis (ALS) using automatic acoustic analysis.Biomedical engineering online · 2024Article
- Acoustic Voice Analysis as a Useful Tool to Discriminate Different ALS Phenotypes.Biomedicines · 2023Article
- At-home wearables and machine learning sensitively capture disease progression in amyotrophic lateral sclerosis.Nature communications · 2023Article
- Responsiveness, Sensitivity and Clinical Utility of Timing-Related Speech Biomarkers for Remote Monitoring of ALS Disease Progression.Interspeech · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Although speech declines rapidly in some individuals with amyotrophic lateral sclerosis (ALS), longitudinal changes in speech have rarely been characterized. The study objectives were to model the rate of decline in speaking rate and speech intelligibility as a function of disease onset site, sex, and age at onset in 166 individuals with ALS; and estimate time to speech loss from symptom onset. We also examined the association between clinical (speaking rate/intelligibility) measures and patient-reported measures of ALS progression (ALSFRS-R). Speech measures declined faster in the bulbar-onset group than in the spinal-onset group. The rate of decline was not significantly affected by sex and age. Functional speech was still maintained at 60 months since disease onset for most patients with spinal onset. However, the time to speech loss was 23 months based on speaking rate < 120 (w/m) and 32 months based on speech intelligibility < 85% in individuals with ALS-bulbar onset. Speech measures were more responsive to functional decline than were the patient-reported measures. The findings of this study will inform future work directed toward improving speech prognosis in ALS, which is critical for determining the appropriate timing of interventions, providing appropriate counseling for patients, and evaluating functional changes during clinical trials.
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