ArticleNature communications2022
Diabetes downregulates the antimicrobial peptide psoriasin and increases E. coli burden in the urinary bladder.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- The urinary microbiome in association with diabetes and diabetic kidney disease: A systematic review.PloS one · 2025Pooled it
- The effect of vitamin D supplementation on antibiotic use: a meta-analysis based on randomized controlled trials.Frontiers in nutrition · 2024Pooled it
- The Urogenital Microbiome-Metabolic Interface in Postmenopausal Recurrent Urinary Tract Infection: Estrogen Deficiency, Diabetes, Obesity, and Microbial Reservoirs.Journal of clinical medicine · 2026Review
- Short-term temporal variation in the early-life gut microbiota links maternal clinical phenotypes to neonatal jaundice.BMC microbiology · 2026Article
- Predictors of Multidrug-Resistant Urinary Tract Infections in Women: A Large Retrospective Cohort Study in a Romanian University Hospital.Microorganisms · 2026Article
- Development of a prediction model for postoperative urinary tract infection in ureteral stone patients based on automated machine learning models.Frontiers in physiology · 2026Article
- Prolonged Suppression of Bacterial Growth in Urine Culture Following Fluoroquinolone Therapy in an Elderly Diabetic Patient: A Diagnostic Pitfall.Infection and drug resistance · 2026Article
- Urinary tract infections in diabetes: clinical significance and management approaches.Acta biochimica Polonica · 2026Review
- Exploring the multifaceted roles of beta-defensins in prediabetes: a detailed review.Frontiers in endocrinology · 2026Review
- Hyperglycemia and type 2 diabetes mellitus associate with postoperative recurrence in chronic rhinosinusitis patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Bacteriostatic and Immunomodulatory Effect of Xylocaine in the Context ofACS bio & med chem Au · 2025Article
- Cystitis glandularis due to Escherichia coli infection in a diabetic Miniature Schnauzer: a case report.BMC veterinary research · 2025Article
- Synthetic antimicrobial peptide LD4-PP protects the host againstFrontiers in immunology · 2025Article
- Nomogram and scoring system for preoperative prediction of the risk of systemic inflammatory response syndrome in one-stage flexible ureteroscopy lithotripsy.Frontiers in surgery · 2025Article
- Current and emerging strategies to curb antibiotic-resistant urinary tract infections.Nature reviews. Urology · 2024Review
- Risk Factors for Recurrent Urinary Tract Infections Among Women in a Large Integrated Health Care Organization in the United States.The Journal of infectious diseases · 2024Article
- Diabetes compromises tight junction protein claudin 14 in the urinary bladder.Cell and tissue research · 2024Article
- Antimicrobial Peptides (AMPs) and the Microbiome in Preterm Infants: Consequences and Opportunities for Future Therapeutics.International journal of molecular sciences · 2024Review
- MV140 Mucosal Vaccine Induces Targeted Immune Response for Enhanced Clearance of UropathogenicVaccines · 2024Article
- Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection.Cell reports · 2024Article
Corrections and comments
- Commented on by
- Commented on byUro-Science.2023
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes is known to increase susceptibility to infections, partly due to impaired granulocyte function and changes in the innate immunity. Here, we investigate the effect of diabetes, and high glucose on the expression of the antimicrobial peptide, psoriasin and the putative consequences for E. coli urinary tract infection. Blood, urine, and urine exfoliated cells from patients are studied. The influence of glucose and insulin is examined during hyperglycemic clamps in individuals with prediabetes and in euglycemic hyperinsulinemic clamped patients with type 1 diabetes. Important findings are confirmed in vivo in type 2 diabetic mice and verified in human uroepithelial cell lines. High glucose concentrations induce lower psoriasin levels and impair epithelial barrier function together with altering cell membrane proteins and cytoskeletal elements, resulting in increasing bacterial burden. Estradiol treatment restores the cellular function with increasing psoriasin and bacterial killing in uroepithelial cells, confirming its importance during urinary tract infection in hyperglycemia. In conclusion, our findings present the effects and underlying mechanisms of high glucose compromising innate immunity.
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