ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2023
Cortico-cortical evoked potentials in response to varying stimulation intensity improves seizure localization.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Methodologies to detect cortico-cortical evoked potentials: a systematic review.Frontiers in human neuroscience · 2025Pooled it
- EEG CONNECT: A proposed reporting checklist for EEG-based connectivity studies in clinical epilepsy research.Epilepsia open · 2026Review
- Corticocortical evoked potential amplitude is altered by cortical stimulation in epilepsy.Epilepsia · 2026Article
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Optimization of cortico-cortical spectral response analysis parameters for seizure onset zone localization.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Adaptation modulates effective connectivity and network stability.Frontiers in computational neuroscience · 2026Article
- Cortico-cortical evoked potentials: Analytical techniques and emerging paradigms for epileptogenic zone localization.Epilepsia · 2025Review
- Review
- Mapping the Epileptogenic Brain Using Low-Frequency Stimulation: Two Decades of Advances and Uncertainties.Journal of clinical medicine · 2025Review
- Anti-Hu associated paraneoplastic upper and lower motor neuropathy triggered by atezolizumab.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Variability of cortico-cortical evoked potentials in the epileptogenic zone is related to seizure occurrence.Annals of clinical and translational neurology · 2024Article
- Network excitability of stimulation-induced spectral responses helps localize the seizure onset zone.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- The high frequency oscillations in the amygdala, hippocampus, and temporal cortex during mesial temporal lobe epilepsy.Cognitive neurodynamics · 2024Article
- The sixth sense: how much does interictal intracranial EEG add to determining the focality of epileptic networks?Brain communications · 2024Article
- Virtual stimulation of the interictal EEG network localizes the EZ as a measure of cortical excitability.Frontiers in network physiology · 2024Article
- Stimulation to probe, excite, and inhibit the epileptic brain.Epilepsia · 2023Article
- Article
- Quantifying trial-by-trial variability during cortico-cortical evoked potential mapping of epileptogenic tissue.Epilepsia · 2023Article
- Physiological and pathological neuronal connectivity in the living human brain based on intracranial EEG signals: the current state of research.Frontiers in network physiology · 2023Review
- A nonlinear relationship of evoked responses following charge-balanced single-pulse electrical stimulation with varying pulse widths.Brain stimulationArticle
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7 authors at 2 institutions in 1 country.
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Abstract
objectiveAs single pulse electrical stimulation (SPES) is increasingly utilized to help localize the seizure onset zone (SOZ), it is important to understand how stimulation intensity can affect the ability to use cortico-cortical evoked potentials (CCEPs) to delineate epileptogenic regions.
methodsWe studied 15 drug-resistant epilepsy patients undergoing intracranial EEG monitoring and SPES with titrations of stimulation intensity. The N1 amplitude and distribution of CCEPs elicited in the SOZ and non-seizure onset zone (nSOZ) were quantified at each intensity. The separability of the SOZ and nSOZ using N1 amplitudes was compared between models using responses to titrations, responses to one maximal intensity, or both.
resultsAt 2 mA and above, the increase in N1 amplitude with current intensity was greater for responses within the SOZ, and SOZ response distribution was maximized by 4-6 mA. Models incorporating titrations achieved better separability of SOZ and nSOZ compared to those using one maximal intensity.
conclusionsWe demonstrated that differences in CCEP amplitude over a range of current intensities can improve discriminability of SOZ regions. SIGNIFICANCE: This study provides insight into the underlying excitability of the SOZ and how differences in current-dependent amplitudes of CCEPs may be used to help localize epileptogenic sites.
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