Evidence map›Paper›PMID 36127097›Full record

ArticleBMJ open2022

The Yorkshire Kidney Screening Trial (YKST): protocol for a feasibility study of adding non-contrast abdominal CT scanning to screen for kidney cancer and other abdominal pathology within a trial of community-based CT screening for lung cancer.

Juliet A Usher-Smith, Angela Godoy, Sarah W Burge, Simon Burbidge, Jon Cartledge, Philip A J Crosbie, Claire Eckert, Fiona Farquhar, David Hammond, Neil Hancock and 14 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05005195 (Yorkshire Kidney Screening Trial), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05005195 naunknown statusnot on this map

Yorkshire Kidney Screening Trial (YKST): a Feasibility Study of Adding Non-contrast Abdominal CT Scan to Chest CT Scan Undertaken in the YLST Randomised Controlled Trial of Community-based CT Screening for Lung Cancer in an at Risk Population to Screen for RCC and Other Abdominal Malignancies

TypeinterventionalSponsorUniversity of LeedsRan2021 to 2023Enrolled5,850ConditionsRenal Cell CarcinomaArmsLow dose abdominal computed tomography scan
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 2 countries.

Juliet A Usher-Smith *Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0002-8501-2531
Angela Godoy *Department of Surgery, University of Cambridge, Cambridge, UK.
Sarah W BurgeDepartment of Oncology, University of Cambridge, Cambridge, UK.
Simon BurbidgeDepartment of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, UK.
Jon CartledgeDepartment of Urology, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, UK.
Philip A J CrosbieDivision of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0001-8941-4813
Claire EckertLeeds Institiute of Health Sciences, University of Leeds, Leeds, UK.
Fiona FarquharResearch and Innovation, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
David HammondResearch and Innovation, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Neil HancockLeeds Diagnosis & Screening Unit, Leeds Institute of Health Sciences, University of Leeds, Leeds, UK.
Gareth R IballDepartment of Medical Physics & Engineering, Leeds teaching hospitals NHS Trust, Leeds, UK.
Michael KimuliDepartment of Urology, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, UK.
Golnessa MassonDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Richard D NealCollege of Medicine and Health, University of Exeter, Exeter, UK.ORCID 0000-0002-3544-2744
Suzanne RogersonResearch and Innovation, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Sabrina H RossiDepartment of Surgery, University of Cambridge, Cambridge, UK.
Evis SalaDepartment of Radiology, University of Cambridge, Cambridge, UK.
Andrew SmithUpper Gastro-intestinal and Pancreas Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Stephen J SharpMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Irene SimmondsLeeds Institiute of Health Sciences, University of Leeds, Leeds, UK.
Tom WallaceLeeds Vascular Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Matthew WardLeeds Institiute of Health Sciences, University of Leeds, Leeds, UK.
Matthew E J CallisterDepartment of Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Grant D StewartDepartment of Surgery, University of Cambridge, Cambridge, UK gds35@cam.ac.uk.ORCID 0000-0003-3188-9140
Leeds Teaching Hospitals NHS Trust · GBUniversity of Cambridge · GBUniversity of Leeds · GBUniversity of Exeter · GBUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionKidney cancer (renal cell cancer (RCC)) is the seventh most common cancer in the UK. As RCC is largely curable if detected at an early stage and most patients have no symptoms, there is international interest in evaluating a screening programme for RCC. The Yorkshire Kidney Screening Trial (YKST) will assess the feasibility of adding non-contrast abdominal CT scanning to screen for RCC and other abdominal pathology within the Yorkshire Lung Screening Trial (YLST), a randomised trial of community-based CT screening for lung cancer. METHODS AND ANALYSIS: In YLST, ever-smokers aged 55-80 years registered with a general practice in Leeds have been randomised to a Lung Health Check assessment, including a thoracic low-dose CT (LDCT) for those at high risk of lung cancer, or routine care. YLST participants randomised to the Lung Health Check arm who attend for the second round of screening at 2 years without a history of RCC or abdominal CT scan within the previous 6 months will be invited to take part in YKST. We anticipate inviting 4700 participants. Those who consent will have an abdominal CT immediately following their YLST thoracic LDCT. A subset of participants and the healthcare workers involved will be invited to take part in a qualitative interview. Primary objectives are to quantify the uptake of the abdominal CT, assess the acceptability of the combined screening approach and pilot the majority of procedures for a subsequent randomised controlled trial of RCC screening within lung cancer screening. ETHICS AND DISSEMINATION: YKST was approved by the North West-Preston Research Ethics Committee (21/NW/0021), and the Health Research Authority on 3 February 2021. Trial results will be disseminated at clinical meetings, in peer-reviewed journals and to policy-makers. Findings will be made available to participants via the study website (www.YKST.org). TRIAL REGISTRATION NUMBERS: NCT05005195 and ISRCTN18055040.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsLung NeoplasmsEarly Detection of CancerFeasibility StudiesHumansKidneyRandomized Controlled Trials as TopicTomography, X-Ray Computedcomputed tomographykidney tumoursurological tumours

Identifiers

PMID36127097
PMCPMC9490622
OpenAlexW4296520345

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.