Evidence map›Paper›PMID 36126675›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2022

Mu-opioid receptor system modulates responses to vocal bonding and distress signals in humans.

Lihua Sun, Lasse Lukkarinen, Vesa Putkinen, Henry K Karlsson, Jussi Hirvonen, Jari Tiihonen, Hannu Lauerma, Sophie Scott, Lauri Nummenmaa

Open access · greenAbstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Pleasurable music activates cerebral µ-opioid receptors: a combined PET-fMRI study.European journal of nuclear medicine and molecular imaging · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Hormone-induced body-brain interaction and the impact on cognition.European journal of nuclear medicine and molecular imaging · 2024
    Article
  9. Cracking the laugh code: laughter through the lens of biology, psychology and neuroscience.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 8 countries.

Lihua SunDepartment of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-9931-9497
Lasse LukkarinenTurku PET Centre, University of Turku, and Turku University Hospital, Turku, Finland.
Vesa PutkinenTurku PET Centre, University of Turku, and Turku University Hospital, Turku, Finland.
Henry K KarlssonTurku PET Centre, University of Turku, and Turku University Hospital, Turku, Finland.
Jussi HirvonenDepartment of Radiology, University of Turku, and Turku University Hospital, Turku, Finland.
Jari TiihonenDepartment of Clinical Neuroscience, Karolinska Institute and Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden.
Hannu LauermaDepartment of Psychiatry, University of Turku, and Turku University Hospital, Turku, Finland.
Sophie ScottInstitute of Cognitive Neuroscience, University College London, London, UK.ORCID 0000-0001-7510-6297
Lauri NummenmaaTurku PET Centre, University of Turku, and Turku University Hospital, Turku, Finland.ORCID 0000-0002-2497-9757
University of Turku · FIFaculty of 1000 (United Kingdom) · GBKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laughter is a contagious prosocial signal that conveys bonding motivation; adult crying conversely communicates desire for social proximity by signalling distress. Endogenous mu-opioid receptors (MORs) modulate sociability in humans and non-human primates. In this combined PET-fMRI study (

Indexed as

Brain MappingLaughterAdultBrainHumansMagnetic Resonance ImagingPositron-Emission Tomographycryingfunctional magnetic resonance imaginglaughteropioid receptorspositron emission tomographysocial cognition

Identifiers

PMID36126675
PMCPMC9489292
OpenAlexW4296781184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.