Evidence map›Paper›PMID 36126269›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2022

Urinary total conjugated 3-bromotyrosine, asthma severity, and exacerbation risk.

Zeneng Wang, Weiling Xu, Suzy A A Comhair, Xiaoming Fu, Zhili Shao, Rebecca Bearden, Joe G Zein, Eugene R Bleecker, Mario Castro, Loren C Denlinger and 10 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Frequent exacerbator-a novel endotype of pediatric asthma.The Journal of allergy and clinical immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 11 institutions in 1 country.

Zeneng WangDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.ORCID 0000-0002-6455-8228
Weiling XuDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Suzy A A ComhairDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Xiaoming FuDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Zhili ShaoDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Rebecca BeardenDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.ORCID 0000-0001-9342-5304
Joe G ZeinRespiratory Institute, Cleveland Clinic, Cleveland, Ohio.
Eugene R BleeckerDepartment of Medicine, University of Arizona Health Sciences, Tucson, Arizona.
Mario CastroDepartment of Medicine, University of Kansas School of Medicine, Kansas City, Kansas.
Loren C DenlingerDivision of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin, Madison, Wisconsin.
John V FahyDepartment of Medicine, San Francisco School of Medicine, University of California, San Francisco, California.ORCID 0000-0001-5427-9308
Elliot IsraelDepartment of Medicine, Harvard Medical School, Harvard University, Boston, Massachusetts.
Bruce D LevyDepartment of Medicine, Harvard Medical School, Harvard University, Boston, Massachusetts.
Nizar N JarjourDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Wendy C MooreDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Sally E WenzelDepartment of Environmental Medicine and Occupational Health, Graduate School of Public Health, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0002-4242-0164
David T MaugerCenter for Biostatistics and Epidemiology, Pennsylvania State University School of Medicine, Hershey, Pennsylvania.
Benjamin GastonWells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana.
Stanley L HazenDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Serpil C ErzurumDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.ORCID 0000-0001-5202-9065
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · USHarvard University · USUniversity of Wisconsin–Madison · USIndiana University School of MedicinePennsylvania State University · USUniversity of Arizona · USUniversity of California, San Francisco · USUniversity of Kansas · USUniversity of Pittsburgh · USWake Forest University · US

Funding

Targeting pathological hyaluronan matricesP01HL103453 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2011 to 2020
$26.8M
Tissue Processing and Cell Culture COreP01HL081064 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2006 to 2019
$17.8M
Clinical Coordinating Center for the Severe Asthma Research Program (SARP)U10HL109086 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MAUGER, DAVID T. · 2011 to 2017
$8.1M
AMSA: ALXR/FBR Mediated Signaling in Severe AsthmaU10HL109172 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT, LEVY, BRUCE D · 2011 to 2016
$4.2M
Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
Implications and Stability of Clinical and Molecular Phenotypes of Severe AsthmaU10HL109152 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WENZEL, SALLY E · 2011 to 2016
$3.9M
Stability of Severe Asthma Phenotypes: Impact of ExacerbationsU10HL109168 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2011 to 2016
$3.9M
Severe Asthma Research Program (SARP)-Washington UniversityU10HL109257 · NHLBI · WASHINGTON UNIVERSITY · PI CASTRO, MARIO · 2011 to 2016
$3.8M
Longitudinal Phenomics and Genetics of Severe AsthmaU10HL109164 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BLEECKER, EUGENE ROLAND, MEYERS, DEBORAH A. · 2011 to 2016
$3.8M
Microbial Trimethylamine Lyases and AtherosclerosisR01HL130819 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI WANG, ZENENG · 2016 to 2019
$1.7M
Gender-based precision care for asthmaK08HL133381 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ZEIN, JOE · 2017 to 2021
$836k
NHLBI NIH HHS K08 HL133381NHLBI NIH HHS P01 HL081064NHLBI NIH HHS P01 HL103453NHLBI NIH HHS R01 HL130819NHLBI NIH HHS U10 HL109086NHLBI NIH HHS U10 HL109152NHLBI NIH HHS U10 HL109164NHLBI NIH HHS U10 HL109168NHLBI NIH HHS U10 HL109172NHLBI NIH HHS U10 HL109250NHLBI NIH HHS U10 HL109257
6 · The paper itself

Abstract

Asthma is an inflammatory disease of the airways characterized by eosinophil recruitment, eosinophil peroxidase release, and protein oxidation through bromination, which following tissue remodeling results in excretion of 3-bromotyrosine. Predicting exacerbations and reducing their frequency is critical for the treatment of severe asthma. In this study, we aimed to investigate whether urinary total conjugated bromotyrosine can discriminate asthma severity and predict asthma exacerbations. We collected urine from participants with severe (

Indexed as

AsthmaEosinophilsEosinophil PeroxidaseGlucuronidaseHumansLeukocyte CountSputumTyrosine3-bromotyrosineEosinophil PeroxidaseGlucuronidaseTyrosine3-bromotyrosineasthmaeosinophilexacerbation

Identifiers

PMID36126269
PMCPMC9602918
OpenAlexW4296492361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.