Evidence map›Paper›PMID 36125923›Full record

ReviewJournal of cellular physiology2022

Molecular mechanisms, physiological roles, and therapeutic implications of ion fluxes in bone cells: Emphasis on the cation-Cl

Alexandre P Garneau, Samira Slimani, Ludwig Haydock, Thy-René Nsimba-Batomene, Florence C M Préfontaine, Mathilde M Lavoie, Laurence E Tremblay, Marie-Jeanne Fiola, Fabrice Mac-Way, Paul Isenring

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of cellular physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Physiological roles of chloride ions in bodily and cellular functions.The journal of physiological sciences : JPS · 2023
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Alexandre P GarneauDepartment of Medicine, Nephrology Research Group, Laval University, Québec, Québec, Canada.
Samira SlimaniDepartment of Medicine, Nephrology Research Group, Laval University, Québec, Québec, Canada.
Ludwig HaydockDepartment of Medicine, Nephrology Research Group, Laval University, Québec, Québec, Canada.
Thy-René Nsimba-BatomeneDepartment of Medicine, Nephrology Research Group, Laval University, Québec, Québec, Canada.
Florence C M PréfontaineDepartment of Medicine, Nephrology Research Group, Laval University, Québec, Québec, Canada.
Mathilde M LavoieDepartment of Medicine, Nephrology Research Group, Laval University, Québec, Québec, Canada.
Laurence E TremblayDepartment of Medicine, Nephrology Research Group, Laval University, Québec, Québec, Canada.
Marie-Jeanne FiolaDepartment of Medicine, Nephrology Research Group, Laval University, Québec, Québec, Canada.
Fabrice Mac-WayDepartment of Medicine, Nephrology Research Group, Laval University, Québec, Québec, Canada.
Paul IsenringDepartment of Medicine, Nephrology Research Group, Laval University, Québec, Québec, Canada.ORCID 0000-0002-5569-6258
Université Laval · CAHôpital Necker-Enfants Malades · FR

Funding

CIHR
6 · The paper itself

Abstract

Bone turnover diseases are exceptionally prevalent in human and come with a high burden on physical health. While these diseases are associated with a variety of risk factors and causes, they are all characterized by common denominators, that is, abnormalities in the function or number of osteoblasts, osteoclasts, and/or osteocytes. As such, much effort has been deployed in the recent years to understand the signaling mechanisms of bone cell proliferation and differentiation with the objectives of exploiting the intermediates involved as therapeutic preys. Ion transport systems at the external and in the intracellular membranes of osteoblasts and osteoclasts also play an important role in bone turnover by coordinating the movement of Ca

Indexed as

OsteocytesSymportersBone DensityBone RemodelingCationsHumansIon TransportSodium-Potassium-Chloride SymportersCationsSodium-Potassium-Chloride SymportersSymportersbone disordersK+-Cl− cotransportersNa+-Cl− cotransportersNa+-K+-Cl− cotransportersosteoblastsosteoclasts

Identifiers

PMID36125923
PMCPMC10087713
OpenAlexW4297855351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.