Evidence map›Paper›PMID 36125655›Full record

ArticleGenes & genomics2022

Genetic variations in the bitter taste receptor gene TAS2R38 are related to cigarette smoking behavior in Han Chinese smokers.

Fei-Yan Qi, Zhou-Hai Zhu, Meng Li, Ying Guan, Qi-Yuan Peng, She-Ming Lu, Zhi-Hua Liu, Ming-Feng Wang, Ming-Ming Miao, Zhang-Yu Chen and 4 more

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Article in Genes & genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Extragustatory bitter taste receptors in head and neck health and disease.Journal of molecular medicine (Berlin, Germany) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Fei-Yan QiJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China.
Zhou-Hai ZhuJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China.
Meng LiJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China.
Ying GuanJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China.
Qi-Yuan PengJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China.
She-Ming LuJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China.
Zhi-Hua LiuJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China.
Ming-Feng WangJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China.
Ming-Ming MiaoJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China.
Zhang-Yu ChenJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China.
Xue-Mei LiJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China.
Jie BaiMedical Faculty, Kunming University of Science and Technology, Kunming, 650500, China.
Jian-Hua YaoJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China. jhyao_2007@126.com.
Jianhua YaoJoint Institute of Tobacco and Health, Kunming, 650106, Yunnan, China.
Kunming University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmoking behavior is influenced by multiple genes, including the bitter taste gene TAS2R38. It has been reported that the correlation between TAS2R38 and smoking behavior has ethnicity-based differences. However, the TAS2R38 status in Chinese smokers is still unclear.

objectiveThis study aims to investigate the possible relationship between genetic variations in TAS2R38 (A49P, V262A and I296V) and smoking behaviors in the Han Chinese population.

methodsThe haplotype analyses were performed and smoking behavior questionnaire was completed by 1271 individuals. Genetic association analyses for smoking behavior were analyzed using chi-square test. Further, for investigating the molecular mechanism of TAS2R38 variants effect on smoking behavior, we conducted TAS2R38-PAV and TAS2R38-AVI expression plasmids and tested the cellular calcium assay by cigarette smoke compounds stimulus in HEK293.

resultsSignificant associations of genetic variants within TAS2R38 were identified with smoking behavior. We found a higher PAV/PAV frequency than AVI/AVI in moderate and high nicotine dependence (FTND ≥ 4; X

conclusionOur data highlights that genetic variations in TAS2R38 are related to smoking behavior, especially nicotine dependence and cigarette smoke flavor intensity preference. Our findings may encourage further consideration of the taste process to identify individuals susceptible to nicotine dependence, particularly Han Chinese smokers.

Indexed as

Cigarette SmokingTobacco Use DisorderCalciumChinaCotinineGenetic VariationHEK293 CellsHumansReceptors, G-Protein-CoupledSmokersTasteTaste Receptors, Type 2CalciumCotinineReceptors, G-Protein-CoupledTaste Receptors, Type 2AlkaloidsBitter taste receptorGenetic variationSmokingTAS2R38

Identifiers

PMID36125655
OpenAlexW4297855250

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.