Evidence map›Paper›PMID 36125641›Full record

ArticleJournal of neuro-oncology2023

Gamma Knife radiosurgery for meningiomas of the confluence of the falx and tentorium.

Hussein M Abdallah, Arka N Mallela, Zhishuo Wei, Hussam Abou-Al-Shaar, Ajay Niranjan, L Dade Lunsford

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hussein M Abdallah *University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Arka N Mallela *Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA. mallelaan@upmc.edu.ORCID http://orcid.org/0000-0003-0993-198X
Zhishuo WeiUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Hussam Abou-Al-ShaarDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Ajay NiranjanDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
L Dade LunsfordDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMeningiomas arising from the confluence of the falx and tentorium (CFT) are a rare and challenging subset of meningiomas. Gamma Knife radiosurgery (GKRS) is well-established as a safe and effective management strategy for intracranial meningiomas, but its role in treating CFT meningiomas is not well-described. This paper reports the largest series focused exclusively on the outcomes of GKRS for CFT meningiomas.

methodsWe retrospectively identified 20 CFT meningiomas out of 2031 meningioma patients who underwent GKRS at our institution between 1987 and 2021. Tumor control, overall survival (OS), and complications were recorded and analyzed. The median tumor margin dose was 13 Gy at the 50% isodose line. The median tumor volume treated was 4.4 cc (IQR 3.5-7.7). The median patient age was 58 years (range 33-83), the median MRI surveillance duration was 59 months (IQR 34-92), and the median overall follow-up duration was 92 months (IQR 42-201).

resultsThe local tumor control rate (PFS) at 5 and 10-years were 100% (N=10) and 83% (N=4), respectively. Eight patients had stable tumor volumes and 11 patients had regression. One patient with a twice-operated tumor had delayed progression at 7.5 years and was retreated with GKRS. No patient had adverse radiation effects during the period of MRI surveillance. The 5 and 10-year OS were 100% (N=13) and 100% (N=7), respectively.

conclusionsGKRS is a valuable therapeutic strategy for patients with newly diagnosed CFT meningiomas or progressive residual tumors after surgical resection.

Indexed as

Meningeal NeoplasmsMeningiomaRadiosurgeryAdultAgedAged, 80 and overFollow-Up StudiesHumansMiddle AgedRetrospective StudiesTreatment OutcomeConfluence of the falx and tentoriumFalcotentorialGamma Knife radiosurgeryKaplan-Meier survivalMeningiomaStereotactic radiosurgery

Identifiers

PMID36125641
OpenAlexW4297855445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.