Evidence map›Paper›PMID 36125604›Full record

ArticleAnnals of biomedical engineering2023

Development and Validation of an Active Muscle Simplified Finite Element Human Body Model in a Standing Posture.

Mitesh Lalwala, Karan S Devane, Bharath Koya, Linh Q Vu, Kevin Dolick, Keegan M Yates, Nathaniel J Newby, Jeffrey T Somers, F Scott Gayzik, Joel D Stitzel and 1 more

Abstract read
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In one paragraph

Article in Annals of biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Mitesh LalwalaDepartment of Biomedical Engineering, Wake Forest University School of Medicine, 575 N. Patterson Ave, Suite 530, Winston-Salem, NC, 27101, USA.
Karan S DevaneDepartment of Biomedical Engineering, Wake Forest University School of Medicine, 575 N. Patterson Ave, Suite 530, Winston-Salem, NC, 27101, USA.
Bharath KoyaDepartment of Biomedical Engineering, Wake Forest University School of Medicine, 575 N. Patterson Ave, Suite 530, Winston-Salem, NC, 27101, USA.
Linh Q VuAegis Aerospace Inc., 2101 NASA Parkway, Houston, TX, 77058, USA.
Kevin DolickGeoControl Systems, 3003 S Loop W #100, Houston, TX, 77054, USA.
Keegan M YatesKBR, 2400 NASA Parkway, Houston, TX, 77058, USA.
Nathaniel J NewbyKBR, 2400 NASA Parkway, Houston, TX, 77058, USA.
Jeffrey T SomersNASA Johnson Space Center, 2101 NASA Parkway, Houston, TX, 77058, USA.
F Scott GayzikDepartment of Biomedical Engineering, Wake Forest University School of Medicine, 575 N. Patterson Ave, Suite 530, Winston-Salem, NC, 27101, USA.
Joel D StitzelDepartment of Biomedical Engineering, Wake Forest University School of Medicine, 575 N. Patterson Ave, Suite 530, Winston-Salem, NC, 27101, USA.
Ashley A WeaverDepartment of Biomedical Engineering, Wake Forest University School of Medicine, 575 N. Patterson Ave, Suite 530, Winston-Salem, NC, 27101, USA. asweaver@wakehealth.edu.ORCID http://orcid.org/0000-0002-4383-0106
Virginia Tech - Wake Forest University School of Biomedical Engineering & Sciences · USKBR (United States) · USGeoControl Systems (United States) · USJohnson Space Center · US

Funding

NASA NNX16AP89GNational Aeronautics and Space Administration NNX16AP89G
6 · The paper itself

Abstract

Active muscles play an important role in postural stabilization, and muscle-induced joint stiffening can alter the kinematic response of the human body, particularly that of the lower extremities, under dynamic loading conditions. There are few full-body human body finite element models with active muscles in a standing posture. Thus, the objective of this study was to develop and validate the M50-PS+Active model, an average-male simplified human body model in a standing posture with active musculature. The M50-PS+Active model was developed by incorporating 116 skeletal muscles, as one-dimensional beam elements with a Hill-type material model and closed-loop Proportional Integral Derivative (PID) controller muscle activation strategy, into the Global Human Body Models Consortium (GHBMC) simplified pedestrian model M50-PS. The M50-PS+Active model was first validated in a gravity standing test, showing the effectiveness of the active muscles in maintaining a standing posture under gravitational loading. The knee kinematics of the model were compared against volunteer kinematics in unsuited and suited step-down tests from NASA's active response gravity offload system (ARGOS) laboratory. The M50-PS+Active model showed good biofidelity with volunteer kinematics with an overall CORA score of 0.80, as compared to 0.64 (fair) in the passive M50-PS model. The M50-PS+Active model will serve as a useful tool to study the biomechanics of the human body in vehicle-pedestrian accidents, public transportation braking, and space missions piloted in a standing posture.

Indexed as

Accidents, TrafficHuman BodyBiomechanical PhenomenaFinite Element AnalysisHumansMaleModels, BiologicalMuscle, SkeletalPostureActive muscleARGOSComputational modelFinite element modelingGHBMCHuman body modelPosture stabilizationReduced gravityStep-down test

Identifiers

PMID36125604
OpenAlexW4297855183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.