Evidence map›Paper›PMID 36125566›Full record

Trial reportArchives of osteoporosis2022

Trabecular bone score in the hip: a new method to examine hip bone microarchitecture-a feasibility study.

Nami Safai Haeri, Subashan Perera, Isabel Ferreiro, Didier Hans, Susan L Greenspan

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Archives of osteoporosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Screening for Osteoporosis in Nonagenarians: A Scoping Review.Journal of the American Geriatrics Society · 2025
    Article
  5. Article
  6. Review
  7. Long-term and sequential treatment for osteoporosis.Nature reviews. Endocrinology · 2023
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Nami Safai HaeriDivision of Geriatric Medicine, Department of Medicine, University of Pittsburgh, 3471 Fifth Ave, Suite 1110, Pittsburgh, PA, 15213, USA. safaihaerin@upmc.edu.
Subashan PereraDivision of Geriatric Medicine, Department of Medicine, University of Pittsburgh, 3471 Fifth Ave, Suite 1110, Pittsburgh, PA, 15213, USA.
Isabel FerreiroMedimaps Group, Bordeaux, France.
Didier HansBone & Joint Department, Center of Bone Diseases, Lausanne University Hospital, Lausanne, Switzerland.
Susan L GreenspanDivision of Geriatric Medicine, Department of Medicine, University of Pittsburgh, 3471 Fifth Ave, Suite 1110, Pittsburgh, PA, 15213, USA.
University of Pittsburgh · USUniversity of Lausanne · CH

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Pitt Integrated Clinical and Geroscience Research Training ProgramT32AG021885 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Aditi U Gurkar · 2003 to 2026
$6.7M
Maintenance of Skeletal Integrity in Frail Elders-Phase 2R01AG050302 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENSPAN, SUSAN L · 2015 to 2019
$3.0M
Long-Term Care Research NetworkK07AG052668 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENSPAN, SUSAN L · 2016 to 2020
$439k
NIA NIH HHS K07 AG052668NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG050302NIA NIH HHS T32 AG021885
6 · The paper itself

Abstract

Our study found, in older adults who are residents of long-term care facilities, assessing hip microarchitecture with DXA-derived bone texture score may serve as a supplement to bone mineral density to improve fracture prediction and to facilitate decision-making for pharmacological management. PURPOSE: Many patients with high fragility fracture risk do not have a sufficiently low bone mineral density (BMD) to become eligible for osteoporosis treatment. They often have deteriorated bone microarchitecture despite a normal or only mildly abnormal BMD. We sought to examine the beta version of the trabecular bone score (TBS) algorithm for the hip: TBS Hip, an indirect index of bone microarchitecture, and assess if TBS Hip brings complementary information to other bone quality indices such as BMD and bone turnover markers (BTMs) to further improve identifying individuals who are at high risk for fractures.

methodsIn this analysis, we considered baseline TBS Hip at total hip, femoral neck, and greater trochanter, TBS at lumbar spine, BMD at all of these skeletal sites, and BTMs in 132 postmenopausal women who were residents of long-term care (LTC) facilities enrolled in a randomized placebo-controlled osteoporosis clinical trial.

resultsOn average, participants were 85.2 years old and had a BMI of 26.9 kg/m

conclusionAmong older women residing in LTC facilities, there was a moderate correlation between measures of BMD and TBS Hip at total hip, femoral neck, and greater trochanter, suggesting TBS Hip may provide complementary information to BMD .

Indexed as

Fractures, BoneOsteoporosisPelvic BonesAbsorptiometry, PhotonAgedAged, 80 and overCancellous BoneFeasibility StudiesFemaleHumansLumbar VertebraeBone microarchitectureBone mineral densityBone texture scoreLong-term care

Identifiers

PMID36125566
PMCPMC12276939
OpenAlexW4296810139

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.