Evidence map›Paper›PMID 36125562›Full record

ArticleJournal of mathematical biology2022

Limits of epidemic prediction using SIR models.

Omar Melikechi, Alexander L Young, Tao Tang, Trevor Bowman, David Dunson, James Johndrow

Abstract read
In one paragraph

Article in Journal of mathematical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  6. Quantifying phage infectivity from characteristics of bacterial population dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Omar MelikechiDepartment of Mathematics, Duke University, Durham, NC, USA. omar.melikechi@duke.edu.ORCID 0000-0003-1052-7300
Alexander L YoungDepartment of Statistics, Harvard University, Cambridge, MA, USA.
Tao TangDepartment of Mathematics, Duke University, Durham, NC, USA.
Trevor BowmanDepartment of Mathematics, Duke University, Durham, NC, USA.
David DunsonDepartment of Mathematics, Duke University, Durham, NC, USA.
James JohndrowDepartment of Statistics, University of Pennsylvania, Philadelphia, PA, USA.

Funding

Structured nonparametric methods for mixtures of exposuresR01ES028804 · NIEHS · DUKE UNIVERSITY · PI DUNSON, DAVID BRIAN · 2018 to 2021
$2.2M
Foundation for the National Institutes of Health R01-ES028804National Science Foundation DMS-2038056NIEHS NIH HHS R01 ES028804
6 · The paper itself

Abstract

The Susceptible-Infectious-Recovered (SIR) equations and their extensions comprise a commonly utilized set of models for understanding and predicting the course of an epidemic. In practice, it is of substantial interest to estimate the model parameters based on noisy observations early in the outbreak, well before the epidemic reaches its peak. This allows prediction of the subsequent course of the epidemic and design of appropriate interventions. However, accurately inferring SIR model parameters in such scenarios is problematic. This article provides novel, theoretical insight on this issue of practical identifiability of the SIR model. Our theory provides new understanding of the inferential limits of routinely used epidemic models and provides a valuable addition to current simulate-and-check methods. We illustrate some practical implications through application to a real-world epidemic data set.

Indexed as

Communicable DiseasesEpidemicsDisease OutbreaksDisease SusceptibilityEpidemiological ModelsHumansEpidemic predictionHypothesis testingIdentifiabilityNonlinear dynamicsParameter inferenceSIR model

Identifiers

PMID36125562
PMCPMC9487859

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.