Evidence map›Paper›PMID 36125373›Full record

ArticleRadiology2023

Gadolinium Deposition in the Rat Brain Measured with Quantitative MRI versus Elemental Mass Spectrometry.

Ning Hua, Olga Minaeva, Nicola Lupoli, Erich S Franz, Xiuping Liu, Juliet A Moncaster, Katharine J Babcock, Hernán Jara, Yorghos Tripodis, Ali Guermazi and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ning Hua *From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.ORCID 0000-0002-8549-3056
Olga Minaeva *From the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.ORCID 0000-0002-7911-6510
Nicola LupoliFrom the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.ORCID 0000-0002-6022-8395
Erich S FranzFrom the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.
Xiuping LiuFrom the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.
Juliet A MoncasterFrom the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.
Katharine J BabcockFrom the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.ORCID 0000-0002-8321-5335
Hernán JaraFrom the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.ORCID 0000-0001-6395-3819
Yorghos TripodisFrom the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.ORCID 0000-0003-2190-7608
Ali GuermaziFrom the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.ORCID 0000-0002-9374-8266
Jorge A SotoFrom the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.ORCID 0000-0003-2533-3015
Stephan W AndersonFrom the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.ORCID 0000-0002-5367-7459
Lee E GoldsteinFrom the Departments of Radiology (N.H., O.M., N.L., X.L., J.A.M., H.J., A.G., J.A.S., S.W.A., L.E.G.), Neurology (L.E.G.), Pathology & Laboratory Medicine (L.E.G.), Anatomy & Neurobiology (K.J.B.), and Biostatistics (Y.T.), Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118; Boston University Alzheimer's Disease Research Center (N.H., O.M., J.A.M., L.E.G.), Boston, Mass; and Center for Biometallomics (O.M., N.L., J.A.M., L.E.G.), College of Engineering (E.S.F., S.W.A., L.E.G.), and Photonics Center (O.M., J.A.M., S.W.A., L.E.G.), Boston University, Boston, Mass.ORCID 0000-0001-8419-9800
Boston University · US

Funding

Neonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain DisordersU01NS040069 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI KUBAN, KARL · 2001 to 2014
$34.0M
SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
RL5: Research Education CoreP30AG072978 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ann C. McKee · 2021 to 2026
$25.6M
The Role of the Placenta-Brain Axis in Children's NeurodevelopmentUH3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Rebecca Fry, Michael O'SHEA · 2018 to 2026
$21.9M
Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk FactorsU01NS093334 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CUMMINGS, JEFFREY L., REIMAN, ERIC MICHAEL · 2016 to 2022
$17.0M
Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical SyndromesU54NS115266 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MCKEE, ANN C. · 2019 to 2023
$10.3M
Leveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD)R01AG061028 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN, MEZ, JESSE BENJAMIN · 2019 to 2023
$5.9M
The Contribution of Age-Related Taupahtoies to Alzheimer's Disease-SupplementR01AG062348 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CRARY, JOHN FONDA, DICKSON, DENNIS WILLIAM · 2018 to 2022
$4.5M
Longitudinal Study of Risk Factors for Mesoamerican Nephropathy among Agricultural Workers in El Salvador, Central AmericaR01ES027584 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SCAMMELL, MADELEINE · 2017 to 2021
$3.6M
Implementing an Intervention to Address Social Determinants of Health in Pediatric PracticesR01HD090191 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GARG, ARVIN · 2017 to 2022
$3.0M
All-Cause and Cause-Specific Mortality Resulting from Non-Fatal Occupational InjuriesR01OH011511 · OH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BODEN, LESLIE I. · 2018 to 2021
$1.5M
MAGNETIC SECTOR FIELD HIGH RESOLUTION MASS SPECTROMETERS10RR021131 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, LEE E · 2006 to 2006
$423k
NCRR NIH HHS S10 RR021131NCRR NIH HHS S10 RR026599NIA NIH HHS P30 AG072978NIA NIH HHS R01 AG061028NIA NIH HHS R01 AG062348NIA NIH HHS R03 AG063250NICHD NIH HHS P30 HD018655NICHD NIH HHS R01 HD090191NIEHS NIH HHS R01 ES027584NIH HHS UH3 OD023348NINDS NIH HHS U01 NS040069NINDS NIH HHS U01 NS093334NINDS NIH HHS U54 NS115266NIOSH CDC HHS R01 OH011511
6 · The paper itself

Abstract

Background T1-weighted MRI and quantitative longitudinal relaxation rate (R1) mapping have been used to evaluate gadolinium retention in the brain after gadolinium-based contrast agent (GBCA) administration. Whether MRI measures accurately reflect gadolinium regional distribution and concentration in the brain remains unclear. Purpose To compare gadolinium retention in rat forebrain measured with in vivo quantitative MRI R1 and ex vivo laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) mapping after gadobenate, gadopentetate, gadodiamide, or gadobutrol administration. Materials and Methods Adult female Sprague-Dawley rats were randomly assigned to one of five groups (eight per group) and administered gadobenate, gadopentetate, gadodiamide, gadobutrol (2.4 mmol/kg per week for 5 weeks), or saline (4.8 mL/kg per week for 5 weeks). MRI R1 mapping was performed at baseline and 1 week after the final injection to determine R1 and ΔR1. Postmortem brains from the same rats were analyzed with LA-ICP-MS elemental mapping to determine regional gadolinium concentrations. Student

Indexed as

GadoliniumOrganometallic CompoundsAnimalsBrainContrast MediaFemaleGadolinium DTPAMagnetic Resonance ImagingMass SpectrometryMeglumineRatsRats, Sprague-DawleyContrast MediagadobutrolgadodiamideGadoliniumGadolinium DTPAMeglumineOrganometallic Compounds

Identifiers

PMID36125373
PMCPMC9792715
OpenAlexW4297855528

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