Evidence map›Paper›PMID 36125307›Full record

ArticleInfection and immunity2022

The Enhancer-Binding Protein MifR, an Essential Regulator of α-Ketoglutarate Transport, Is Required for Full Virulence of Pseudomonas aeruginosa PAO1 in a Mouse Model of Pneumonia.

Weichuan Xiong, Alexander Perna, Ikechukwu B Jacob, Benjamin R Lundgren, Guirong Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Deletion ofFrontiers in immunology · 2026
    Article
  2. Transcriptional Regulators Controlling Virulence inInternational journal of molecular sciences · 2023
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Weichuan XiongDepartment of Surgery, State University of New York (SUNY) Upstate Medical University, Syracuse, New York, USA.
Alexander PernaDepartment of Surgery, State University of New York (SUNY) Upstate Medical University, Syracuse, New York, USA.
Ikechukwu B JacobDepartment of Surgery, State University of New York (SUNY) Upstate Medical University, Syracuse, New York, USA.
Benjamin R LundgrenDepartment of Biology, The College of New Jersey, Ewing, New Jersey, USA.ORCID 0000-0002-6556-120X
Guirong WangDepartment of Surgery, State University of New York (SUNY) Upstate Medical University, Syracuse, New York, USA.
SUNY Upstate Medical University · USCollege of New Jersey · USNanchang University · CN

Funding

Mechanisms of differential susceptibility of human SP-B genetic variants to pneumonia and lung injuryR01HL136706 · NHLBI · UPSTATE MEDICAL UNIVERSITY · PI WANG, GUIRONG · 2017 to 2020
$1.6M
Defining the inputs and outputs of enhancer-binding protein regulation in Pseudomonas aeruginosaR15GM104880 · NIGMS · COLLEGE OF ENVIRONMENTAL SCI & FORESTRY · PI LEYDET, BRIAN F. · 2013 to 2018
$1.3M
NHLBI NIH HHS R01 HL136706NIGMS NIH HHS R15 GM104880
6 · The paper itself

Abstract

The opportunistic human pathogen Pseudomonas aeruginosa PAO1 has an extensive metabolism, enabling it to utilize a wide range of structurally diverse compounds to meet its nutritional and energy needs. Interestingly, the utilization of some of the more unusual compounds often associated with a eukaryotic-host environment is regulated via enhancer-binding proteins (EBPs) in P. aeruginosa. Whether the utilization of such compounds and the EBPs involved contribute to the pathogenesis of P. aeruginosa remains to be fully understood. To narrow this gap, we investigated the roles of the EBPs EatR (regulator of ethanolamine catabolism), DdaR (regulator of methylarginine catabolism), and MifR (regulator of α-ketoglutarate or α-KG transport) in the virulence of P. aeruginosa PAO1 in a pneumonia-induced septic mouse model. Deletion of genes encoding EatR and DdaR had no significant effect on the mortality of P. aeruginosa PAO1-infected mice compared to wide-type (WT) PAO1-infected mice. In contrast, infected mice with Δ

Indexed as

PneumoniaPseudomonas InfectionsAnimalsBacterial ProteinsCytokinesDisease Models, AnimalDNA-Binding ProteinsEthanolaminesHumansInflammasomesKetoglutaric AcidsMiceNLR Family, Pyrin Domain-Containing 3 ProteinPseudomonas aeruginosaVirulenceBacterial ProteinsCytokinesDNA-Binding ProteinsEthanolaminesInflammasomesKetoglutaric AcidsNLR Family, Pyrin Domain-Containing 3 Proteinacute infectionalpha-ketoglutarateenhancer-binding proteinMifRP. aeruginosaseptic mouse modelvirulence factors

Identifiers

PMID36125307
PMCPMC9584295
OpenAlexW4296781799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.