Evidence map›Paper›PMID 36125288›Full record

ArticleMicrobiology spectrum2022

Utilization of the Abbott SARS-CoV-2 IgG II Quant Assay To Identify High-Titer Anti-SARS-CoV-2 Neutralizing Plasma against Wild-Type and Variant SARS-CoV-2 Viruses.

Yi-Chan J Lin, David H Evans, Ninette F Robbins, Guillermo Orjuela, Queenie Hu, Reuben Samson, Kento T Abe, Bhavisha Rathod, Karen Colwill, Anne-Claude Gingras and 4 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Yi-Chan J LinDepartment of Medical Microbiology & Immunology, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.
David H EvansDepartment of Medical Microbiology & Immunology, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.ORCID 0000-0001-5871-299X
Ninette F RobbinsScientific Affairs, Abbott Transfusion Medicine, Chicago, Illinois, USA.
Guillermo OrjuelaScientific Affairs, Abbott Transfusion Medicine, Bogotá, Colombia.
Queenie HuLunenfeld-Tanenbaum Research Institute at Mt. Sinai Hospital, Sinai Health, Toronto, Ontario, Canada.
Reuben SamsonLunenfeld-Tanenbaum Research Institute at Mt. Sinai Hospital, Sinai Health, Toronto, Ontario, Canada.
Kento T AbeLunenfeld-Tanenbaum Research Institute at Mt. Sinai Hospital, Sinai Health, Toronto, Ontario, Canada.
Bhavisha RathodLunenfeld-Tanenbaum Research Institute at Mt. Sinai Hospital, Sinai Health, Toronto, Ontario, Canada.
Karen ColwillLunenfeld-Tanenbaum Research Institute at Mt. Sinai Hospital, Sinai Health, Toronto, Ontario, Canada.
Anne-Claude GingrasLunenfeld-Tanenbaum Research Institute at Mt. Sinai Hospital, Sinai Health, Toronto, Ontario, Canada.
Ashleigh TuiteDalla Lana School of Public Health, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
Qi-Long YiEpidemiology and Surveillance, Canadian Blood Servicesgrid.423370.1, Ottawa, Ontario, Canada.
Sheila F O'BrienEpidemiology and Surveillance, Canadian Blood Servicesgrid.423370.1, Ottawa, Ontario, Canada.ORCID 0000-0002-5332-2789
Steven J DrewsCanadian Blood Servicesgrid.423370.1, Microbiology, Edmonton, Alberta, Canada.ORCID 0000-0003-2519-1109
University of Toronto · CALunenfeld-Tanenbaum Research Institute · CAUniversity of Alberta · CAUniversity of Ottawa · CAAbbott (United States) · US

Funding

CIHR VR2-172723
6 · The paper itself

Abstract

There is evidence that COVID-19 convalescent plasma may improve outcomes of patients with impaired immune systems; however, more clinical trials are required. Although we have previously used a 50% plaque reduction/neutralization titer (PRNT

Indexed as

COVID-19SARS-CoV-2Antibodies, NeutralizingAntibodies, ViralHumansImmunoglobulin GAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GCOVID-19 convalescent plasmamethod comparisonsneutralizing antibodyplaque reduction neutralizationSARS-CoV-2 antibody

Identifiers

PMID36125288
PMCPMC9602363
OpenAlexW4296782706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.