Evidence map›Paper›PMID 36125273›Full record

ArticlemBio2022

Uncovering Lasonolide A Biosynthesis Using Genome-Resolved Metagenomics.

Siddharth Uppal, Jackie L Metz, René K M Xavier, Keshav Kumar Nepal, Dongbo Xu, Guojun Wang, Jason C Kwan

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Jaspamide/Jasplakinolide Is Synthesized byJournal of natural products · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. β-Lactams from the Ocean.Marine drugs · 2023
    Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Siddharth UppalDivision of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jackie L MetzHarbor Branch Oceanographic Institute, Florida Atlantic Universitygrid.255951.f, Boca Raton, Florida, USA.
René K M XavierHarbor Branch Oceanographic Institute, Florida Atlantic Universitygrid.255951.f, Boca Raton, Florida, USA.
Keshav Kumar NepalHarbor Branch Oceanographic Institute, Florida Atlantic Universitygrid.255951.f, Boca Raton, Florida, USA.
Dongbo XuHarbor Branch Oceanographic Institute, Florida Atlantic Universitygrid.255951.f, Boca Raton, Florida, USA.
Guojun WangHarbor Branch Oceanographic Institute, Florida Atlantic Universitygrid.255951.f, Boca Raton, Florida, USA.ORCID 0000-0001-6416-2744
Jason C KwanDivision of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-9933-1536
Florida Atlantic University · USUniversity of Wisconsin–Madison · US

Funding

Identifying the biosynthesis of a potent cytotoxic agent Lasonolide AR21CA209189 · NCI · FLORIDA ATLANTIC UNIVERSITY · PI WANG, GUOJUN · 2016 to 2017
$384k
NCI NIH HHS R21 CA209189
6 · The paper itself

Abstract

Invertebrates, particularly sponges, have been a dominant source of new marine natural products. For example, lasonolide A (LSA) is a potential anticancer molecule isolated from the marine sponge

Indexed as

Antineoplastic AgentsBiological ProductsPoriferaAcyl Carrier ProteinAcyltransferasesAnimalsBacteriaMacrolidesMetagenomicsPhylogenyPolyketide SynthasesRNA, Ribosomal, 16SSymbiosisAcyl Carrier ProteinAcyltransferasesAntineoplastic AgentsBiological Productslasonolide AMacrolidesPolyketide SynthasesRNA, Ribosomal, 16Sgenome reductionhorizontal gene transferlasonolide Amultiple repeatssymbiosistrans-AT PKSVerrucomicrobia

Identifiers

PMID36125273
PMCPMC9600693
OpenAlexW4296483925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.