Evidence map›Paper›PMID 36125130›Full record

ArticleeLife2022

Bone marrow adipocytes drive the development of tissue invasive Ly6C

Parastoo Boroumand, David C Prescott, Tapas Mukherjee, Philip J Bilan, Michael Wong, Jeff Shen, Ivan Tattoli, Yuhuan Zhou, Angela Li, Tharini Sivasubramaniyam and 7 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Neutrophils as indicators of obesity-associated inflammation: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Bone marrow adipocytes: key players in vascular niches, aging, and disease.Frontiers in cell and developmental biology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Monocyte regulation by gut microbial signals.Trends in microbiology · 2023
    Review
  12. Review
  13. Review
  14. Review
  15. Immunometabolism at the Heart of Cardiovascular Disease.JACC. Basic to translational science · 2023
    Review
  16. Review
  17. Article
  18. New role for bone marrow adipocytes in obesity.Nature reviews. Endocrinology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Parastoo BoroumandCell Biology Program, The Hospital for Sick Children, Toronto, Canada.
David C PrescottDepartment of Immunology, University of Toronto, Toronto, Canada.
Tapas MukherjeeDepartment of Immunology, University of Toronto, Toronto, Canada.
Philip J BilanCell Biology Program, The Hospital for Sick Children, Toronto, Canada.
Michael WongCell Biology Program, The Hospital for Sick Children, Toronto, Canada.
Jeff ShenCell Biology Program, The Hospital for Sick Children, Toronto, Canada.
Ivan TattoliDepartment of Laboratory Medicine and Pathophysiology, University of Toronto, Toronto, Canada.
Yuhuan ZhouCell Biology Program, The Hospital for Sick Children, Toronto, Canada.
Angela LiToronto General Hospital Research Institute, Toronto, Canada.
Tharini SivasubramaniyamToronto General Hospital Research Institute, Toronto, Canada.
Nancy ShiCell Biology Program, The Hospital for Sick Children, Toronto, Canada.
Lucie Y ZhuCell Biology Program, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0002-1048-5377
Zhi LiuCell Biology Program, The Hospital for Sick Children, Toronto, Canada.
Clinton RobbinsDepartment of Laboratory Medicine and Pathophysiology, University of Toronto, Toronto, Canada.
Dana J PhilpottDepartment of Immunology, University of Toronto, Toronto, Canada.
Stephen E GirardinDepartment of Immunology, University of Toronto, Toronto, Canada.
Amira KlipCell Biology Program, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0001-7906-0302
University of Toronto · CAHospital for Sick Children · CAToronto General Hospital · CA

Funding

CIHR FDN-143203CIHR FDN-14333
6 · The paper itself

Abstract

During obesity and high fat-diet (HFD) feeding in mice, sustained low-grade inflammation includes not only increased pro-inflammatory macrophages in the expanding adipose tissue, but also bone marrow (BM) production of invasive Ly6C

Indexed as

Bone MarrowMonocytesAdipocytesAnimalsCulture Media, ConditionedMiceMice, Inbred C57BLObesityCulture Media, Conditionedbone marrow adipocytesbone marrow monocytesglycolytic shiftimmunologyimmunometabolisminflammationmedicinemouseobesity

Identifiers

PMID36125130
PMCPMC9512398
OpenAlexW4296309536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.