ArticleeLife2022
Distance estimation from monocular cues in an ethological visuomotor task.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Visual computation in the cephalopod brain.Current opinion in neurobiology · 2026Review
- PSD-95 drives binocular vision maturation critical for predation.bioRxiv : the preprint server for biology · 2026Article
- Visual uncertainty and task demands shape active sensing strategies in mice.Current biology : CB · 2026Article
- Ecological Visual Processing in the Mouse.Annual review of neuroscience · 2026Review
- Visual uncertainty and task demands shape active sensing strategies in mice.bioRxiv : the preprint server for biology · 2026Article
- Vision guides directed orienting movements during obstacle avoidance in mice.bioRxiv : the preprint server for biology · 2026Article
- A spinal substrate for modular control of natural behavior.bioRxiv : the preprint server for biology · 2026Article
- Motor Skill Deficits and Associated Factors in Childhood Intermittent Exotropia: A Cross-Sectional Study.Investigative ophthalmology & visual science · 2026Article
- Flexible computation of object motion and depth based on viewing geometry inferred from optic flow.Nature communications · 2025Article
- Resourcefulness, Robustness, and Recovery: Tail Use during Climbing in Rats.Integrative and comparative biology · 2025Article
- The Richness of Vision in the Mammalian Brain: Neural Codes for Visual Perception and Behavior in Three Dimensions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Visual circuitry for distance estimation in Drosophila.Current biology : CB · 2025Article
- DISSeCT: An unsupervised framework for high-resolution mapping of rodent behavior using inertial sensors.PLoS biology · 2025Article
- Seeing a Three-Dimensional World in Motion: How the Brain Computes Object Motion and Depth During Self-Motion.Annual review of vision science · 2025Review
- A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics.Nature neuroscience · 2025Article
- Characterization of depth perception information inferred from neuronal activity in primary visual cortex.PloS one · 2025Article
- Building egocentric models of local space from retinal input.Current biology : CB · 2024Review
- Sound-seeking before and after hearing loss in mice.Scientific reports · 2024Article
- Development of the Binocular Circuit.Annual review of neuroscience · 2024Review
- A pupillary contrast response in mice and humans: Neural mechanisms and visual functions.Neuron · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
In natural contexts, sensory processing and motor output are closely coupled, which is reflected in the fact that many brain areas contain both sensory and movement signals. However, standard reductionist paradigms decouple sensory decisions from their natural motor consequences, and head-fixation prevents the natural sensory consequences of self-motion. In particular, movement through the environment provides a number of depth cues beyond stereo vision that are poorly understood. To study the integration of visual processing and motor output in a naturalistic task, we investigated distance estimation in freely moving mice. We found that mice use vision to accurately jump across a variable gap, thus directly coupling a visual computation to its corresponding ethological motor output. Monocular eyelid suture did not affect gap jumping success, thus mice can use cues that do not depend on binocular disparity and stereo vision. Under monocular conditions, mice altered their head positioning and performed more vertical head movements, consistent with a shift from using stereopsis to other monocular cues, such as motion or position parallax. Finally, optogenetic suppression of primary visual cortex impaired task performance under both binocular and monocular conditions when optical fiber placement was localized to binocular or monocular zone V1, respectively. Together, these results show that mice can use monocular cues, relying on visual cortex, to accurately judge distance. Furthermore, this behavioral paradigm provides a foundation for studying how neural circuits convert sensory information into ethological motor output.
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