ArticleJournal of pharmacokinetics and biopharmaceutics1987
Time-dependent variations in the organ extraction ratios of acetaminophen in rat.
Article in Journal of pharmacokinetics and biopharmaceutics, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Organoid models of ovarian cancer: resolving immune mechanisms of metabolic reprogramming and drug resistance.Frontiers in immunology · 2025Review
- A microfluidic 3D hepatocyte chip for hepatotoxicity testing of nanoparticles.Nanomedicine (London, England) · 2019Article
- Influence of the Time of Intravenous Administration of Paracetamol on its Pharmacokinetics and Ocular Disposition in Rabbits.European journal of drug metabolism and pharmacokinetics · 2017Article
- The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Gait analysis in rats with single joint inflammation: influence of experimental factors.PloS one · 2012Article
- Age-related pseudocapillarization of the liver sinusoidal endothelium impairs the hepatic clearance of acetaminophen in rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
- Scaling basic toxicokinetic parameters from rat to man.Environmental health perspectives · 1996Review
- The effect of moderate hemodilution with fluosol-DA or normal saline on acetaminophen disposition in the rat.Experientia · 1990Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pharmacokinetics of a single 40 mg/kg dose of acetaminophen was investigated at 09h00 and 21h00 in Sprague-Dawley rats synchronized to a 12-h light-dark cycle. Acetaminophen was administered by the intraarterial, intravenous, intraperitoneal, and oral routes in order to determine the contribution of the gastrointestinal tract, liver, and lung to the oral extraction ratio of the drug. A mean oral extraction ratio of 0.46 was obtained at 21h00 as compared to 0.39 at 09h00. The mean extraction ratios of the gastrointestine, liver, and lung were 0.05, 0.41, and 0 at 09h00 and 0.18, 0.24, and 0.13 at 21h00, respectively. These results indicate that the extrahepatic metabolism of acetaminophen is important at 21h00, but is barely detectable at 09h00, whereas the hepatic extraction ratio is higher at 09h00 than at 21h00. Thus, there are temporal variations in the disposition of acetaminophen in the rat.
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Registered trials
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