Evidence map›Paper›PMID 36124971›Full record

SynthesisRheumatology (Oxford, England)2023

Individual participant data meta-analysis of metabolomics on sustained knee pain in primary osteoarthritis patients.

Christie A Costello, Jason S Rockel, Ming Liu, Rajiv Gandhi, Anthony V Perruccio, Y Raja Rampersaud, Nizar N Mahomed, Proton Rahman, Edward W Randell, Andrew Furey and 2 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Rheumatology (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Christie A CostelloDivision of Biomedical Sciences (Genetics), Faculty of Medicine, Memorial University of Newfoundland, St John's, NL, Canada.ORCID 0000-0002-5013-9380
Jason S RockelOsteoarthritis Research Program, Division of Orthopedics, Schroeder Arthritis Institute, University, Health Network, Toronto, ON, Canada.
Ming LiuDivision of Biomedical Sciences (Genetics), Faculty of Medicine, Memorial University of Newfoundland, St John's, NL, Canada.
Rajiv GandhiOsteoarthritis Research Program, Division of Orthopedics, Schroeder Arthritis Institute, University, Health Network, Toronto, ON, Canada.
Anthony V PerruccioOsteoarthritis Research Program, Division of Orthopedics, Schroeder Arthritis Institute, University, Health Network, Toronto, ON, Canada.
Y Raja RampersaudOsteoarthritis Research Program, Division of Orthopedics, Schroeder Arthritis Institute, University, Health Network, Toronto, ON, Canada.
Nizar N MahomedOsteoarthritis Research Program, Division of Orthopedics, Schroeder Arthritis Institute, University, Health Network, Toronto, ON, Canada.
Proton RahmanDiscipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Edward W RandellDiscipline of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Andrew FureyDivision of Orthopaedics, Faculty of Medicine, Memorial University of Newfoundland, St John's, NL, Canada.
Mohit KapoorOsteoarthritis Research Program, Division of Orthopedics, Schroeder Arthritis Institute, University, Health Network, Toronto, ON, Canada.
Guangju ZhaiDivision of Biomedical Sciences (Genetics), Faculty of Medicine, Memorial University of Newfoundland, St John's, NL, Canada.
Memorial University of Newfoundland · CAUniversity Health Network · CA

Funding

CIHR 132178CIHR 143058CIHR 153298
6 · The paper itself

Abstract

objectivesKnee pain is the major driver for OA patients to seek healthcare, but after pursuing both conservative and surgical pain interventions, ∼20% of patients continue to report long-term pain following total knee arthroplasty (TKA). This study aimed to identify a metabolomic signature for sustained knee pain after TKA to elucidate possible underlying mechanisms.

methodsTwo independent cohorts from St John's, NL, Canada (n = 430), and Toronto, ON, Canada (n = 495) were included in the study. Sustained knee pain was assessed using the WOMAC pain subscale (five questions) at least 1 year after TKA for primary OA. Those reporting any pain on all five questions were considered to have sustained knee pain. Metabolomic profiling was performed on fasted pre-operative plasma samples using the Biocrates Absolute IDQ p180 kit. Associations between metabolites and pair-wise metabolite ratios with sustained knee pain in each individual cohort were assessed using logistic regression with adjustment for age, sex and BMI. Random-effects meta-analysis using inverse variance as weights was performed on summary statistics from both cohorts.

resultsOne metabolite, phosphatidylcholine (PC) diacyl (aa) C28:1 (odds ratio = 0.66, P = 0.00026), and three metabolite ratios, PC aa C32:0 to PC aa C28:1, PC aa C28:1 to PC aa C32:0, and tetradecadienylcarnitine (C14:2) to sphingomyelin C20:2 (odds ratios = 1.59, 0.60 and 1.59, respectively; all P < 2 × 10-5), were significantly associated with sustained knee pain.

conclusionsThough further investigations are needed, our results provide potential predictive biomarkers and drug targets that could serve as a marker for poor response and be modified pre-operatively to improve knee pain and surgical response to TKA.

Indexed as

Arthroplasty, Replacement, KneeOsteoarthritisOsteoarthritis, KneeHumansKnee JointMetabolomicsPainTreatment Outcomeknee painmetabolomicsOAsustained paintotal knee arthroplasty

Identifiers

PMID36124971
PMCPMC10152299
OpenAlexW4296471426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.