Evidence map›Paper›PMID 36124931›Full record

ArticleThe Journal of international medical research2022

Elevated alanine aminotransferase is associated with biphasic insulin secretion in the healthy elderly Han Chinese population.

Tzong-Yow Wu, En-Chih Liao, Yen-Lin Chen, Yung-Feng Lin, Shu-Hsiang Liu, Hua-Ching Lin, Yi-Chou Chiu, Chung-Ze Wu, Jiunn-Diann Lin, Dee Pei and 1 more

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Article in The Journal of international medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Tzong-Yow WuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei.
En-Chih LiaoDepartment of Medicine, MacKay Medical College, New Taipei.
Yen-Lin ChenDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Centre, Taipei.
Yung-Feng LinSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei.
Shu-Hsiang LiuSchool of Nursing, College of Nursing, National Taipei University of Nursing and Health Science, Taipei.
Hua-Ching LinDepartment of Surgery, Division of Colorectal Surgery, Cheng Hsin General Hospital, Taipei.
Yi-Chou ChiuDepartment of Surgery, Division of General Surgery, Cheng Hsin General Hospital, Taipei.
Chung-Ze WuDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Shuang Ho Hospital, Taipei Medical University, New Taipei.
Jiunn-Diann LinDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Shuang Ho Hospital, Taipei Medical University, New Taipei.
Dee PeiSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei.
Chun-Hsien HsuSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei.ORCID 0000-0001-8023-8454
Fu Jen Catholic University · TWTaipei Medical University-Shuang Ho Hospital · TWCheng Hsin General Hospital · TWMackay Medical University · TWMing Chuan University · TWNational Taipei University of Nursing and Health Science · TWNational Taiwan University Hospital · TWTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the relationship between alanine transaminase (ALT) level and biphasic insulin secretion (BPIS) in healthy elderly Han Chinese individuals.

methodsThis cross-sectional study enrolled healthy elderly participants aged ≥60 years that were part of a health examination programme. In order to explore the correlation and severity of the clinical condition, those with any possible confounding factors known to affect insulin secretion or liver function were excluded from the study. BPIS was calculated using an equation developed previously by this research team.

resultsThis study enrolled 39 845 healthy elderly individuals (19 058 males and 20 787 females). Participants were stratified into four quartile groups according to their ALT level. In both males and females, the increasing ALT quartiles (ordinal variable) were associated with greater values of log-transformed first-phase insulin secretion (FPIS) and second-phase insulin secretion (SPIS). The correlation and the linear regression model showed that increasing ALT level was significantly correlated with higher log-transformed FPIS and SPIS.

conclusionsALT was positively correlated with BPIS in a healthy elderly population in both men and women. Elevated ALT may serve as an indicating factor for developing metabolic syndrome and type 2 diabetes mellitus in healthy elderly individuals.

Indexed as

Biphasic InsulinsDiabetes Mellitus, Type 2AgedAlanine TransaminaseChinaCross-Sectional StudiesFemaleHumansInsulin SecretionMaleAlanine TransaminaseBiphasic Insulinsalanine transaminasebiphasic insulin secretionelderlyliver enzymesNonalcoholic fatty liver diseasetype 2 diabetes mellitus

Identifiers

PMID36124931
PMCPMC9511325
OpenAlexW4296783803

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.