ArticleCerebral cortex (New York, N.Y. : 1991)2023
Age differences in the functional organization of the prefrontal cortex: analyses of competing hypotheses.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Hierarchical disruption of lateral prefrontal cortex gradients in cognitive aging.GeroScience · 2026Article
- Different structural brain patterns and their association with executive function and general cognitive ability in cognitively normal elderly adults.Frontiers in aging neuroscience · 2026Article
- Neural correlates of span capacity during visual discrimination under varying cognitive demands.Scientific reports · 2025Article
- Brain-Cognition Fingerprinting via Graph-GCCA with Contrastive Learning.Machine learning in clinical neuroimaging : 7th international workshop, MLCN 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 10, 2024, proceedings. MLCN (Workshop) (7th : 2024 : Marrakesh, Morocco) · 2025Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We employed a mixed design task for block and event-related functional magnetic resonance imaging with manipulations of levels of abstraction and duration in task-relevant cues and probes. Age-related differences between younger and older adults in task-related functional brain activity patterns of the prefrontal cortex (PFC) were reported. The results showed that (1) the low episodic condition evoked more activity in the more anterior PFC than the high episodic control condition for both age groups; (2) the low abstraction condition evoked more activity in the more anterior PFC than the high abstraction condition for both age groups; and (3) the signal change did not vary as a function of activity dynamics (transient and sustained responses) and maintenance duration (single-trial and multiple-trial). The findings showed that baseline conditions evoked more activity in the more anterior PFC for the older group than the younger group across most task contrasts and conditions, where these additional activities in the brain regions overlapped within the default mode network (DMN). We tentatively concluded that deficiency in the anterior DMN deactivation during externally driven tasks might be attributed to less efficiency in modulating local connectivity propagate to surrounding tissue, which may paradoxically increase brain activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.