ArticleThe Journal of clinical endocrinology and metabolism2022
The SELFI Study: Iodine Excess and Thyroid Dysfunction in Women Undergoing Oil-Soluble Contrast Hysterosalpingography.
Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Contrast media for hysterosalpingography: systematic search and review providing new guidelines by the Contrast Media Safety Committee of the European Society of Urogenital Radiology.European radiology · 2024Pooled it
- Intrauterine infusion of oil-based medium in women with recurrent implantation failure before frozen embryo transfer: a randomized clinical trial.Reproductive health · 2025Trial
- Neurodevelopmental outcomes of school-age children conceived after hysterosalpingography with oil-based or water-based iodinated contrast: long-term follow-up of a nationwide randomized controlled trial.Human reproduction (Oxford, England) · 2024Trial
- The impact of prolonged, maternal iodine exposure in early gestation on neonatal thyroid function.Frontiers in endocrinology · 2023Trial
- Iodine deficiency in the first pregnancy trimester and intelligence in adolescence.European journal of nutrition · 2026Article
- Ethiodized oil interference of planned radioiodine therapy post thoracic duct embolization: report of 2 cases.JCEM case reports · 2026Article
- Iodinated contrast media (ICM)-induced thyroid dysfunction: a review of potential mechanisms and clinical management.Clinical and experimental medicine · 2025Review
- The relationship between excessive iodine during pregnancy and adverse pregnancy complications.Endocrine · 2025Article
- From deficiency to excess: the impact of iodine excess on reproductive health.Frontiers in endocrinology · 2025Review
- Article
- Oil-soluble contrast medium bathing attenuated endometrial inflammation and improved endometrial receptivity in women with recurrent implantation failure: a descriptive study.BMC women's health · 2024Article
- Effects of iodine intake on gut microbiota and gut metabolites in Hashimoto thyroiditis-diseased humans and mice.Communications biology · 2024Article
- Iodine and other factors associated with fertility outcome following oil-soluble contrast medium hysterosalpingography: a prospective cohort study.Frontiers in endocrinology · 2024Article
- Response to Letter to the Editor From Marin et al: "The SELFI Study: Iodine Excess and Thyroid Dysfunction in Women Undergoing Oil-Soluble Contrast Hysterosalpingography".The Journal of clinical endocrinology and metabolism · 2023Article
- The effectiveness of immediate versus delayed tubal flushing with oil-based contrast in women with unexplained infertility (H2Oil-timing study): study protocol of a randomized controlled trial.BMC women's health · 2023Article
- Iodine-induced thyroid dysfunction: a scientometric study and visualization analysis.Frontiers in endocrinology · 2023Article
- Effect of interval time between hysterosalpingography and intrauterine insemination on the pregnancy outcome of infertile patients.Frontiers in endocrinology · 2023Article
- The SELFI Study: Iodine Excess and Thyroid Dysfunction in Women Undergoing Oil-Soluble Contrast Hysterosalpingography.The Journal of clinical endocrinology and metabolism · 2022Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
contextHysterosalpingography (HSG) with oil-soluble contrast medium (OSCM) improves pregnancy rates. However, OSCM has high iodine content and long half-life, leading to potential iodine excess.
objectiveThis work aimed to determine the pattern of iodine excess after OSCM HSG and the effect on thyroid function.
methodsA prospective cohort study was conducted of 196 consecutive consenting eligible women without overt hypothyroidism or hyperthyroidism. All completed the study with compliance greater than 95%. Participants underwent OSCM HSG (Auckland, 2019-2021) with serial monitoring of thyrotropin (TSH), free thyroxine (FT4), and urine iodine concentration (UIC) for 24 weeks. The main outcome measure was the development of subclinical hypothyroidism (SCH), defined as a nonpregnant TSH greater than 4 mIU/L with normal FT4 (11-22 pmol/L) in those with normal baseline thyroid function.
resultsIodine excess (UIC ≥ 300 μg/L) was almost universal (98%) with UIC peaking usually by 4 weeks. There was marked iodine excess, with 90% and 17% of participants having UIC greater than or equal to 1000 μg/L and greater than 10 000 μg/L, respectively. Iodine excess was prolonged with 67% having a UIC greater than or equal to 1000 μg/L for at least 3 months. SCH developed in 38%; the majority (96%) were mild (TSH 4-10 mIU/L) and most developed SCH by week 4 (75%). Three participants met the current treatment guidelines (TSH > 10 mIU/L). Thyroxine treatment of mild SCH tended to improve pregnancy success (P = .063). Hyperthyroidism (TSH < 0.3 mIU/L) occurred in 9 participants (5%).
conclusionOSCM HSG resulted in marked and prolonged iodine excess. SCH occurred frequently with late-onset hyperthyroidism occasionally. Regular thyroid function tests are required for 6 months following this procedure.
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