ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Genetic and Environmental Influences on Longitudinal Frailty Trajectories From Adulthood into Old Age.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty.Nature aging · 2025Pooled it
- Predicting Frailty Trajectories Using Interpretable Machine Learning Among Older Adults Following Hip Surgery: Prospective Longitudinal Study.JMIR aging · 2026Observational
- Frailty and genetics: linking molecular aging to clinical vulnerability.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Perceived Environmental Age Friendliness and Frailty Among Community-Dwelling Older Adults.JAMA network open · 2026Article
- Epidemiological approaches to refine biomarkers of aging.Nature aging · 2026Article
- Relationships between physical activity dimensions and frailty incidence and progression in middle-aged and older adults: A 7-year cohort study.Journal of exercise science and fitness · 2026Article
- A Longitudinal Study of the Bidirectional Temporal Dynamics Between Body Mass Index and Biological Aging.Journal of cachexia, sarcopenia and muscle · 2025Article
- Breast cancer-specific survival by molecular subtype in different age groups of women in Scotland.Breast cancer research : BCR · 2025Article
- Impact of impaired intrinsic capacity on postoperative frailty in elderly patients undergoing colorectal surgery: study protocol for a single-center, prospective, cohort study.Frontiers in aging neuroscience · 2025Article
- Prevalence and determinants of multidimensional frailty in hospitalized older adults with coronary heart disease: a LASSO regression analysis.Frontiers in cardiovascular medicine · 2025Article
- Metallothionein-1A (MT1A) Gene Variability May Play a Role in Female Frailty: A Preliminary Study.Genes · 2024Article
- Secular trends in frailty among community-dwelling 75-95-year-old cohorts over three decades in Helsinki, Finland.Age and ageing · 2024Article
- Translatability of life-extending pharmacological treatments between different species.Aging cell · 2024Review
- Article
- Midlife cumulative deficit frailty predicts Alzheimer's disease-related plasma biomarkers in older adults.Age and ageing · 2024Article
- Frailty and Processing Speed Performance at the Cusp of Midlife in CATSLife.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty is a complex, dynamic geriatric condition, but limited evidence has shown how genes and environment may contribute to its longitudinal changes. We sought to investigate sources of individual differences in the longitudinal trajectories of frailty, considering potential selection bias when including a sample of oldest-old twins.
methodsData were from 2 Swedish twin cohort studies: a younger cohort comprising 1 842 adults aged 29-96 years followed up to 15 waves, and an older cohort comprising 654 adults aged ≥79 years followed up to 5 waves. Frailty was measured using the frailty index (FI). Age-based latent growth curve models were used to examine longitudinal trajectories, and extended to a biometric analysis to decompose variability into genetic and environmental etiologies.
resultsA bilinear model with an inflection point at age 75 best described the data, indicating a fourfold to fivefold faster FI increase after 75 years. Twins from the older cohort had significantly higher mean FI at baseline but slower rate of increase afterward. FI level at age 75 was moderately heritable in both men (42%) and women (55%). Genetic influences were relatively stable across age for men and increasing for women, although the most salient amplification in FI variability after age 75 was due to individual-specific environmental influences for both men and women; conclusions were largely consistent when excluding the older cohort.
conclusionIncreased heterogeneity of frailty in late life is mainly attributable to environmental influences, highlighting the importance of targeting environmental risk factors to mitigate frailty in older adults.
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