Evidence map›Paper›PMID 36124714›Full record

ArticleCell proliferation2022

Mutant C/EBPα p30 alleviates immunosuppression of CD8

Jun-Dan Wang, Jue-Qiong Xu, Xue-Ning Zhang, Ze-Wei Huang, Ling-Ling Liu, Ling Zhang, Xin-Xing Lei, Man-Jie Xue, Jian-Yu Weng, Zi-Jie Long

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jun-Dan WangDepartment of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jue-Qiong XuDepartment of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xue-Ning ZhangDepartment of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ze-Wei HuangDepartment of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ling-Ling LiuDepartment of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ling ZhangDepartment of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xin-Xing LeiSun Yat-sen University Cancer Center, Guangzhou, China.
Man-Jie XueMedical Research Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jian-Yu WengDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zi-Jie LongDepartment of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-1616-6019
Sun Yat-sen University · CNGuangdong Academy of Medical Sciences · CN

Funding

Guangdong Basic and Applied Basic Research Foundation 2022A1515012533
6 · The paper itself

Abstract

objectivesMutant C/EBPα p30 (mp30), the product of C/EBPα double mutations (DM), lacks transactivation domain 1 and has C-terminal loss-of-function mutation. Acute myeloid leukaemia (AML) patients harbouring C/EBPα DM could be classified as a distinct subgroup with favourable prognosis. However, the underlying mechanism remains elusive. MATERIALS AND

methodsAutophagy regulated by mp30 was detected by western blot and immunofluorescence. Immune infiltration analysis and GSEA were performed to investigate autophagic and inflammatory status of AML patients from the GSE14468 cohort. Flow cytometry was applied to analyse T cell activation.

resultsMp30 inhibited autophagy by suppressing nucleus translocation of NF-κB. Autophagy-associated secretion of IL-1β was decreased in mp30-overexpressed AML cells. Bioinformatic analysis revealed that inflammatory status was attenuated, while CD8

conclusionsC/EBPα DM alleviates immunosuppression of CD8

Indexed as

CCAAT-Enhancer-Binding Protein-alphaLeukemia, Myeloid, AcuteAutophagyCD8-Positive T-LymphocytesHumansImmunosuppression TherapyLeukocytes, MononuclearCCAAT-Enhancer-Binding Protein-alpha

Identifiers

PMID36124714
PMCPMC9715362
OpenAlexW4296781231

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.