ArticleNeuro-oncology2023
Response assessment in pediatric craniopharyngioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) Working Group.
Article in Neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus.British journal of cancer · 2026Article
- Assessment of paediatric craniopharyngioma progression: a comparison of contrast-enhanced and non-contrast MRI.Neuroradiology · 2026Article
- Long-term outcomes of paediatric craniopharyngiomas: a comparison of two large international series.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Observational
- AI-powered segmentation and prognosis with missing MRI in pediatric brain tumors.NPJ precision oncology · 2026Article
- White paper on the current state of imaging biomarkers in paediatric oncology.Pediatric radiology · 2025Review
- Response Assessment in Neuro-Oncology (RANO) 2009-2025: Broad scope and implementation-A progress report.Neuro-oncology · 2025Review
- The use of minor response, volumetric assessment, and growth rate kinetics as endpoints in grade 1-3 glioma clinical trials: a RANO perspective.Neuro-oncology · 2025Review
- Prolactin serum concentrations in childhood-onset craniopharyngioma patients.Journal of endocrinological investigation · 2025Observational
- Operative performance of RAPNO DIPG imaging criteria-a study from the International DIPG/DMG Registry.Neuro-oncology practice · 2025Article
- Management of Acquired Hypothalamic Obesity After Childhood-Onset Craniopharyngioma-A Narrative Review.Biomedicines · 2025Review
- Response assessment in pediatric neurooncology (RAPNO) criteria revisited: a practical navigation guide for neuroradiologists.Neuroradiology · 2024Review
- Towards consistency in pediatric brain tumor measurements: Challenges, solutions, and the role of artificial intelligence-based segmentation.Neuro-oncology · 2024Review
- Approaches to supratentorial brain tumours in children.Neuroradiology · 2024Review
- Current state and promise of user-centered design to harness explainable AI in clinical decision-support systems for patients with CNS tumors.Frontiers in radiology · 2024Review
- Basics for Pediatric Brain Tumor Imaging: Techniques and Protocol Recommendations.Brain tumor research and treatment · 2024Review
- Feasibility, tolerability, and first experience of intracystic treatment with peginterferon alfa-2a in patients with cystic craniopharyngioma.Frontiers in oncology · 2024Article
- Review of imaging recommendations from Response Assessment in Pediatric Neuro-Oncology (RAPNO).Pediatric radiology · 2023Review
- The Price of Success-The Long-Term Outcomes of Children with Craniopharyngioma-Two Institutions' Experience.Children (Basel, Switzerland) · 2023Article
- Evolution and implementation of radiographic response criteria in neuro-oncology.Neuro-oncology advancesReview
- Radio-pathomic approaches in pediatric neuro-oncology: Opportunities and challenges.Neuro-oncology advancesReview
Corrections and comments
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Authors and funding
24 authors at 18 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCraniopharyngioma is a histologically benign tumor of the suprasellar region for which survival is excellent but quality of life is often poor secondary to functional deficits from tumor and treatment. Standard therapy consists of maximal safe resection with or without radiation therapy. Few prospective trials have been performed, and response assessment has not been standardized.
methodsThe Response Assessment in Pediatric Neuro-Oncology (RAPNO) committee devised consensus guidelines to assess craniopharyngioma response prospectively.
resultsMagnetic resonance imaging is the recommended radiologic modality for baseline and follow-up assessments. Radiologic response is defined by 2-dimensional measurements of both solid and cystic tumor components. In certain clinical contexts, response to solid and cystic disease may be differentially considered based on their unique natural histories and responses to treatment. Importantly, the committee incorporated functional endpoints related to neuro-endocrine and visual assessments into craniopharyngioma response definitions. In most circumstances, the cystic disease should be considered progressive only if growth is associated with acute, new-onset or progressive functional impairment.
conclusionsCraniopharyngioma is a common pediatric central nervous system tumor for which standardized response parameters have not been defined. A RAPNO committee devised guidelines for craniopharyngioma assessment to uniformly define response in future prospective trials.
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