Evidence map›Paper›PMID 36124439›Full record

ArticleBiomolecules & biomedicine2023

Analysis of cardiac manifestation and treatment of multisystem inflammatory syndrome in children related to SARS-CoV-2.

Stasa Krasic, Sanja Ninic, Sergej Prijic, Sasa Popovic, Srdjan Pasic, Gordana Petrovic, Boris Zec, Snezana Ristic, Dejan Nesic, Luka Nikolic and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules & biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Stasa KrasicCardiology Department, Faculty of Medicine, Mother and Child Health Institute of Serbia, University of Belgrade, Belgrade, Serbia.
Sanja NinicCardiology Department, Faculty of Medicine, Mother and Child Health Institute of Serbia, University of Belgrade, Belgrade, Serbia.
Sergej PrijicCardiology Department, Faculty of Medicine, Mother and Child Health Institute of Serbia, University of Belgrade, Belgrade, Serbia.
Sasa PopovicCardiology Department, Faculty of Medicine, Mother and Child Health Institute of Serbia, University of Belgrade, Belgrade, Serbia.
Srdjan PasicImmunology Department, Faculty of Medicine, Mother and Child Health Institute of Serbia, University of Belgrade, Belgrade, Serbia.
Gordana PetrovicImmunology Department, Faculty of Medicine, Mother and Child Health Institute of Serbia, University of Belgrade, Belgrade, Serbia.
Boris ZecPediatric Clinic, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina.
Snezana RisticIntensive care unit, Mother and Child Health Institute of Serbia, Belgrade, Serbia.
Dejan NesicInstitute of Medical Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Luka NikolicCardiology Department, Faculty of Medicine, Mother and Child Health Institute of Serbia, University of Belgrade, Belgrade, Serbia.
Vladislav VukomanovicCardiology Department, Faculty of Medicine, Mother and Child Health Institute of Serbia, University of Belgrade, Belgrade, Serbia.
University of Belgrade · RSInstitute of Public Health of Serbia · RSUniversity clinical center of Republika Srpska · BA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular manifestations are common (35-100%) in the multisystem inflammatory syndrome in children. Our study aimed to analyze treatment impact and cardiovascular involvement in patients with multisystem inflammatory syndrome in children. The retrospective cohort included 81 patients treated between April 2020 and December 2021 (9.3±4.6 years). Elevated cardiac troponin I and pro-B-type natriuretic peptide were observed in 34.2% and 88.5% of patients, respectively. Myocardial dysfunction was observed in 50.6%. Children older than 10 years had a 4-fold increased risk of myocardial dysfunction (odds ratio [OR] 3.6, 95% confidence interval [CI] 1.4-8.9; p=0.006). A moderate negative correlation was proved between left ventricle ejection fraction and C-reactive protein (rr = - 0.48; p < 0.001). More than one-fifth of the patients presented with shock. Coronary artery dilatation was observed in 6.2% of patients. Mild pericardial effusion was detected in 27.1% of children. On standard electrocardiogram, 52.6% of children had negative T waves in the inferior and/or precordial leads; transient QTc prolongation was registered in 43% of patients. Treatment failure was observed in 19 patients. Patients initially treated with intravenous immunoglobulins had 10-fold higher chances for treatment failure than patients treated with corticosteroids (OR 10.6, 95% CI 3,18 - 35.35; p < 0.001). Cardiovascular manifestations were observed in more than half of the patients, with acute myocardial dysfunction being the most common, especially in children older than 10 years. We established a negative association between the degree of elevation of inflammatory markers and left ventricular ejection fraction. Patients treated with intravenous immunoglobulins who had cardiovascular manifestations had treatment failures more frequently than patients treated with corticosteroids.

Indexed as

COVID-19SARS-CoV-2ChildChild, PreschoolHumansImmunoglobulins, IntravenousRetrospective StudiesStroke VolumeSystemic Inflammatory Response SyndromeVentricular Function, LeftImmunoglobulins, Intravenous

Identifiers

PMID36124439
PMCPMC10113947
OpenAlexW4296235856

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.