ArticleMicrosystems & nanoengineering2022
Grid cell remapping under three-dimensional object and social landmarks detected by implantable microelectrode arrays for the medial entorhinal cortex.
Article in Microsystems & nanoengineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Highly mechanically stable PEDOT:PSS/PDA-modified microelectrode arrays reveal state-specific dynamic neural activity across sleep-wake.Microsystems & nanoengineering · 2026Article
- The Contribution of Spatially Tuned Brain Cells to Human Navigation Performance.KN - journal of cartography and geographic information · 2026Review
- Mechanistic research on the vestibular-hippocampal pathway in neurodegenerative diseases: an integrative perspective from molecular to behavioral levels.Frontiers in neuroscience · 2026Review
- Neuronal activity in the ventral tegmental area during goal-directed navigation recorded by low-curvature microelectrode arrays.Microsystems & nanoengineering · 2024Article
- Tentacle Microelectrode Arrays Uncover Soft Boundary Neurons in Hippocampal CA1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- High-Throughput Microelectrode Arrays for Precise Functional Localization of the Globus Pallidus Internus.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Grid cells: the missing link in understanding Parkinson's disease?Frontiers in neuroscience · 2024Article
- Improved Navigation Performance Through Memory Triggering Maps: AKN - journal of cartography and geographic information · 2024Review
- Microelectrode Arrays for Detection of Neural Activity in Depressed Rats: Enhanced Theta Activity in the Basolateral Amygdala.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Using Human-Induced Pluripotent Stem Cell Derived Neurons on Microelectrode Arrays to Model Neurological Disease: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Recent Progress and Perspectives on Neural Chip Platforms Integrating PDMS-Based Microfluidic Devices and Microelectrode Arrays.Micromachines · 2023Review
- Impaired Spatial Firing Representations of Neurons in the Medial Entorhinal Cortex of the Epileptic Rat Using Microelectrode Arrays.Research (Washington, D.C.) · 2023Article
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Authors and funding
14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Grid cells with stable hexagonal firing patterns in the medial entorhinal cortex (MEC) carry the vital function of serving as a metric for the surrounding environment. Whether this mechanism processes only spatial information or involves nonspatial information remains elusive. Here, we fabricated an MEC-shaped microelectrode array (MEA) to detect the variation in neural spikes and local field potentials of the MEC when rats forage in a square enclosure with a planar, three-dimensional object and social landmarks in sequence. The results showed that grid cells exhibited rate remapping under social conditions in which spike firing fields closer to the social landmark had a higher firing rate. Furthermore, global remapping showed that hexagonal firing patterns were rotated and scaled when the planar landmark was replaced with object and social landmarks. In addition, when grid cells were activated, the local field potentials were dominated by the theta band (5-8 Hz), and spike phase locking was observed at troughs of theta oscillations. Our results suggest the pattern separation mechanism of grid cells in which the spatial firing structure and firing rate respond to spatial and social information, respectively, which may provide new insights into how the brain creates a cognitive map.
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