Evidence map›Paper›PMID 36123712›Full record

ArticleDiabetology & metabolic syndrome2022

Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes.

Panpan He, Xiaoqin Gan, Qimeng Wu, Ziliang Ye, Sisi Yang, Yanjun Zhang, Huan Li, Chun Zhou, Yuanyuan Zhang, Mengyi Liu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Panpan HeDivision of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
Xiaoqin GanDivision of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
Qimeng WuDivision of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
Ziliang YeDivision of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
Sisi YangDivision of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
Yanjun ZhangDivision of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
Huan LiDivision of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
Chun ZhouDivision of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
Yuanyuan ZhangDivision of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
Mengyi LiuDivision of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
Xianhui QinDivision of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China. pharmaqin@126.com.
Guangzhou Regenerative Medicine and Health Guangdong Laboratory · CNNanfang Hospital · CNSouthern Medical University · CN

Funding

National Key Research and Development Program 2022YFC2009600National Natural Science Foundation of China 81730019National Natural Science Foundation of China 81973133Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University 2017J009
6 · The paper itself

Abstract

backgroundWe aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular mortality and total mortality in patients with diabetes.

methodsAmong 5194 participants with type 2 diabetes enrolled in the ACCORD lipid trial, VVVs of LDL-C, triglycerides, HDL-C, and HbA1c were assessed from baseline to 2 years of follow-up and expressed as coefficient of variation (CV). The study outcomes included cardiovascular mortality and all-cause mortality.

resultsOver a median follow-up of 3.0 years from the end of variability measurements at years 2, there were 305 (5.9%) cases of all-cause mortality, of which, 144 were cardiovascular causes. The positive relations between LDL-C CV and cardiovascular mortality were significantly stronger among participants with higher HDL-C CV (P for interaction = 0.023), and higher HbA1c CV (P for interaction = 0.015). However, there were no significant interactions between LDL-C CV and triglycerides CV (P for interaction = 0.591). Similar trends were found for all-cause mortality. Consistently, there were graded trends in the risk of mortality with the increasing numbers of higher CV of the three variables: LDL-C, HbA1c, and HDL-C (P for trend = 0.008 for cardiovascular mortality, and P for trend < 0.001 for all-cause mortality).

conclusionVVVs in LDL-C, HDL-C, and HbA1c may jointly affect the risks of cardiovascular and all-cause mortality in diabetes patients. Those with higher CVs of all three variables had the highest risks of cardiovascular and all-cause mortality.

Indexed as

MortalityType 2 diabetesVisit-to-visit HbA1c variabilityVisit-to-visit HDL-C variabilityVisit-to-visit LDL-C variability

Identifiers

PMID36123712
PMCPMC9487118
OpenAlexW4296367867

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.