ArticleBMC psychiatry2022
Elevated levels of monocyte-lymphocyte ratio and platelet-lymphocyte ratio in adolescents with non-suicidal self-injury.
Article in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Analysis of complete blood counts and derived inflammatory indices with non-suicidal self-injury and suicide attempt in adolescents with major depressive disorder.Frontiers in psychiatry · 2026Article
- Low-grade inflammatory parameters may be associated with recent suicide attempts - a naturalistic study among psychiatric inpatients with depressive disorders.Frontiers in psychiatry · 2026Article
- Inflammatory indices are associated with non-suicidal self-injury in adolescents with major depressive disorder.BMC psychiatry · 2025Article
- Associations between peripheral plasma cytokine levels and patterns of non-suicidal self-injury methods among Chinese outpatient adolescents: a latent class analysis.BMC psychiatry · 2025Article
- The role of cytokines in predicting the therapeutic effect of non-suicidal self-injury in adolescents: a longitudinal study.BMC psychiatry · 2025Article
- Intrinsic Links Between Non-Suicidal Self-Injury and Sleep Quality and Cytokines: A Network Analysis Based on Chinese Adolescents with Depressive Disorders.Psychology research and behavior management · 2025Article
- Association of Blood Cell-Derived Inflammatory Markers with Symptoms and Short-Term Treatment Response in Late-Life Depression.Neuropsychiatric disease and treatment · 2025Article
- Immunological alterations in patients with current and lifetime suicide ideation and attempts: Examining the relationship with depressive symptoms.Brain, behavior, & immunity - health · 2024Article
- Microplastics exposure altered hematological and lipid profiles as well as liver and kidney function parameters in albino rats (Rattus norvegicus).Environmental analysis, health and toxicology · 2024Article
- A cross-sectional study of non-suicidal self-injury in adolescent depression: association with demographic characteristics and physiological indicators.Frontiers in psychiatry · 2024Article
- Inflammatory Hematological Ratios in Adolescents with Mental Disorders: A Scoping Review.Consortium psychiatricum · 2024Article
- Attention TurkerNeXt: Investigations into Bipolar Disorder Detection Using OCT Images.Diagnostics (Basel, Switzerland) · 2023Article
- Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio in depressed patients with suicidal behavior: A systematic review.European psychiatry : the journal of the Association of European Psychiatrists · 2023Review
- Being overweight and obese increases suicide risk, the severity of depression, and the inflammatory response in adolescents with major depressive disorders.Frontiers in immunology · 2023Article
- The relationship between the monocyte-to-lymphocyte ratio and osteoporosis in postmenopausal females with T2DM: A retrospective study in Chinese population.Frontiers in endocrinology · 2023Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) are blood indicators of systemic inflammation. This study aims to compare the levels of inflammatory indicators derived from blood routine tests between adolescents with non-suicidal self-injury (NSSI) and those with non-NSSI.
methodsA total of 201 adolescents with mood or emotional disorders were enrolled in this study, among which 106 had engaged in NSSI and 95 had never engaged in NSSI. NLR, MLR, and PLR were calculated based on the complete blood cell count.
resultsThere was no significant difference in demographic data between the two groups. The NSSI group exhibited significantly higher MLR (P = 0.001) and PLR (P = 0.007) than the non-NSSI group. Multivariate logistic regression analysis revealed that MLR (OR 1.545, 95%CI [1.087-2.281], P = 0.021) and PLR (OR 1.327, 95%CI [1.215-1.450], P < 0.001) were independently associated with NSSI. Receiver operating characteristic (ROC) curve analyses demonstrated that for differentiating NSSI from non-NSSI, the optimal cut-off value of MLR was 0.135 and the area under curve was 0.638 ([0.561- 0.715], P < 0.001), with a sensitivity of 90.60% and a specificity of 33.70%; the optimal cut-off value of PLR was 127.505 and the area under curve was of 0.611 ([0.533-0.689], P < 0.001), with a sensitivity of 39.60% and a specificity of 81.10%.
conclusionsSystemic inflammation, as indicated by elevated MLR and PLR, was found to be strongly associated with NSSI among adolescents.
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