Evidence map›Paper›PMID 36123638›Full record

Trial reportBMC pregnancy and childbirth2022

The hematological impact of umbilical cord milking versus delayed cord clamping in premature neonates: a randomized controlled trial.

Hytham Atia, Ahmed Badawie, Osama Elsaid, Mahmoud Kashef, Nourhan Alhaddad, Mohamed Gomaa

Retracted Registry-linked trialOpen access · goldAbstract readRandomized Controlled TrialRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to trial NCT03147846 (The Hematologic Impact of Umbilical Cord Milking Versus Deferred Cord Clamping in Premature Neonates. A Randomized Controlled Trial), which is not on this map. Cited by 4 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03147846 nacompletednot on this map

The Hematologic Impact of Umbilical Cord Milking Versus Deferred Cord Clamping in Premature Neonates. A Randomized Controlled Trial

TypeinterventionalSponsorZagazig UniversityRan2017 to 2019Enrolled200ConditionsDelayed Cord Clamping, Umbilical Cord Milking, Preterm NeonatesArmsdelayed cord clamping, cord milking
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Hytham AtiaFaculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt. hythamatia@gmail.com.ORCID http://orcid.org/0000-0002-4013-9491
Ahmed BadawieArmed Forces Hospitals Southern Region, King Faisal Military City Hospital, Base-villa 68, King Faisal military city, 62417-8183, Khamis Mushait, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0002-8134-9743
Osama ElsaidArmed Forces Hospitals Southern Region, King Faisal Military City Hospital, Base-villa 68, King Faisal military city, 62417-8183, Khamis Mushait, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0001-9038-5968
Mahmoud KashefArmed Forces Hospitals Southern Region, King Faisal Military City Hospital, Base-villa 68, King Faisal military city, 62417-8183, Khamis Mushait, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0002-6573-8925
Nourhan AlhaddadAl Ahmady Hospital, Madina, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0002-8546-5135
Mohamed GomaaArmed Forces Hospitals Southern Region, King Faisal Military City Hospital, Base-villa 68, King Faisal military city, 62417-8183, Khamis Mushait, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0001-8929-8306
Armed Forces Hospital · SAZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe hematological impact of umbilical cord milking (UCM) was compared to that of delayed cord clamping (DCC) as a faster placental transfusion technique for preterm neonates (between 24 and 34 + 6 weeks gestation). A comparison of important neonatal morbidities was also made.

methodsThis was an open-label randomized trial conducted from June 8, 2017, to April 22, 2019. Two hundred patients with preterm deliveries (24 and 34 + 6 weeks gestation) were assigned to the DCC or UCM group at random at a ratio of 1:1. The study power was 80% for a difference in the hematocrit value of 3% and Hb value of one gram, and an alpha error of 0.05.

resultsThe following variables were analyzed in the comparison of UCM vs. DCC: first draw hemoglobin: 17.0 ± 1.9 vs. 16.8 ± 1.8 gm/dl (95% CI -0.75-0.29, P 0.383); first draw hematocrit: 55.6 ± 6.4 vs. 55.2 ± 6.4% (95% CI -2.18-1.38, P 0.659); peak hematocrit: 56.9 ± 6.4 vs. 56.3 ± 6.7% (95% CI -2.41-1.26, P 0.537); the need for respiratory assistance (47% vs. 30%, P 0.020), inotropes (16% vs. 6%, P 0.040), and blood transfusion (26% vs. 12%, P 0.018); and the occurrence of intraventricular hemorrhage (9% vs. 5%, P 0.407), necrotizing enterocolitis (6% vs. 2%, P 0.279), sepsis (25% vs. 15%, P 0.111), and neonatal death (13% vs. 4%, P 0.40).

conclusionUCM facilitated a rapid transfer of placental blood equivalent to that of DCC for premature neonates. However, it resulted in increased rates of interventions and morbidities, especially in extremely preterm neonates.

trial registrationThe clinical trial was registered on May 10, 2017, with registration number (NCT03147846).

Indexed as

Infant, Newborn, DiseasesUmbilical Cord ClampingConstrictionFemaleHemoglobinsHumansInfant, NewbornInfant, PrematurePlacentaPregnancyUmbilical CordHemoglobinsCord milkingDeferred clampingHematocritPlacental transfusionPreterm

Identifiers

PMID36123638
PMCPMC9484179
OpenAlexW4296351275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.