ArticleThe ISME journal2022
Sequential interspecies interactions affect production of antimicrobial secondary metabolites in Pseudomonas protegens DTU9.1.
Article in The ISME journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Synthetic microbial communities for studying the fate and ecological role of specialized metabolites.Essays in biochemistry · 2026Review
- A Dual-Receptor System MediatesJournal of agricultural and food chemistry · 2026Article
- Isolation and Genomic Characterization of a Novel Japanese Strain of Pseudomonas protegens and an Evaluation of Its Biocontrol Potential.Microbes and environments · 2026Article
- Lineage-restricted genomic islands drive rhizosphere niche specialization inISME communications · 2026Article
- GacA uses two distinct regulatory mechanisms to control the biosynthesis of 2,4-diacetylphloroglucinol inApplied and environmental microbiology · 2025Article
- Pseudomonas protegens as a biocontrol agent against phytopathogenic fungi - mini review.World journal of microbiology & biotechnology · 2025Review
- Interspecies signaling modulates the biosynthesis of antimicrobial secondary metabolites related to biological control activities ofMicrobiology spectrum · 2025Article
- Antimycobacterial activity of intertidal sediment-derived bacteria from False Bay, South Africa.Frontiers in microbiology · 2025Article
- Pyoluteorin-deficient Pseudomonas protegens improves cooperation with Bacillus velezensis, biofilm formation, co-colonizing, and reshapes rhizosphere microbiome.NPJ biofilms and microbiomes · 2024Article
- Taxonomy ofmSystems · 2024Article
- Antibiotic-producing plant-associated bacteria, anti-virulence therapy and microbiome engineering: Integrated approaches in sustainable agriculture.Microbial biotechnology · 2024Article
- Enrichment of novel entomopathogenic Pseudomonas species enhances willow resistance to leaf beetles.Microbiome · 2024Article
- Multiple Chitin- or Avirulent Strain-Triggered Immunity Induces Microbiome Reassembly in Rice.Microorganisms · 2024Article
- Pyoluteorin regulates the biosynthesis of 2,4-DAPG through the TetR family transcription factor PhlH inApplied and environmental microbiology · 2024Article
- Resistance towards and biotransformation of a Pseudomonas-produced secondary metabolite during community invasion.The ISME journal · 2024Article
- Succession of microbial community composition and secondary metabolism during marine biofilm development.ISME communications · 2024Article
- Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Soil and rhizosphere microbiomes play important roles in suppression of plant pathogens through production of antagonistic secondary metabolites, yet mechanisms that determine the strength of pathogen control are not well understood. Many Pseudomonas species are associated with soil and rhizosphere microbiomes, and their ability to suppress pathogens is well documented. Here, we investigate how interactions within the Pseudomonas genus affect their production of antimicrobial metabolites. From a biosensor-based screen, we identify P. capeferrum species as capable of modulating secondary metabolite production in P. protegens. We show that P. capeferrum alters production of pyoluteorin and 2,4-diacetylphloroglucinol (DAPG) in P. protegens via two distinct and sequential mechanisms that depends on spatial proximity of the two species. Specifically, P. capeferrum secretes a diffusible signal that induce pyoluteorin production up to 100-fold in neighboring P. protegens colonies. In contrast, the interaction results in reduced DAPG production, but only within mixed-species colonies. Additionally, we found that increased pyoluteorin production and cell lysis of P. capeferrum is required for inhibition of DAPG production, suggesting that pyoluteorin-facilitated antibiosis of P. protegens on P. capeferrum leads to release of cell-associated metabolites and subsequent inhibition of DAPG production in P. protegens. As the interaction modulates in vitro bioactivity of the species, genus-specific interactions may assist in improving efficacy of biocontrol strains and consortia.
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