ArticleNature communications2022
Transformation of primary sensory cortical representations from layer 4 to layer 2.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
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- Adapting and facilitating responses in mouse somatosensory cortex are dynamic and shaped by experience.Current biology : CB · 2024Article
- Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity.Research square · 2024Article
- Stimulus information guides the emergence of behavior-related signals in primary somatosensory cortex during learning.Cell reports · 2024Article
- Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity.bioRxiv : the preprint server for biology · 2024Article
- The tuning of tuning: How adaptation influences single cell information transfer.PLoS computational biology · 2024Article
- Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition.bioRxiv : the preprint server for biology · 2024Article
- Cortical circuitry mediating interareal touch signal amplification.Cell reports · 2023Article
- Automating licking bias correction in a two-choice delayed match-to-sample task to accelerate learning.Scientific reports · 2023Article
- Representational drift in barrel cortex is receptive field dependent.bioRxiv : the preprint server for biology · 2023Article
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- Sparse and distributed cortical populations mediate sensorimotor integration.bioRxiv : the preprint server for biology · 2023Article
- Microstimulation of sensory cortex engages natural sensory representations.Current biology : CB · 2023Article
- Input-specific synaptic depression shapes temporal integration in mouse visual cortex.bioRxiv : the preprint server for biology · 2023Article
- Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex.Nature communications · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Sensory input arrives from thalamus in cortical layer (L) 4, which outputs predominantly to superficial layers. L4 to L2 thus constitutes one of the earliest cortical feedforward networks. Despite extensive study, the transformation performed by this network remains poorly understood. We use two-photon calcium imaging to record neural activity in L2-4 of primary vibrissal somatosensory cortex (vS1) as mice perform an object localization task with two whiskers. Touch responses sparsen and become more reliable from L4 to L2, with nearly half of the superficial touch response confined to ~1 % of excitatory neurons. These highly responsive neurons have broad receptive fields and can more accurately decode stimulus features. They participate disproportionately in ensembles, small subnetworks with elevated pairwise correlations. Thus, from L4 to L2, cortex transitions from distributed probabilistic coding to sparse and robust ensemble-based coding, resulting in more efficient and accurate representations.
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