ArticleNature communications2022
Flexible cue anchoring strategies enable stable head direction coding in both sighted and blind animals.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Ecological Visual Processing in the Mouse.Annual review of neuroscience · 2026Review
- Diversity and sensorimotor specialization of head direction cells in the mouse thalamus.Current biology : CB · 2026Article
- The contribution of cross-modal sensory input to reaching and grasping in blind and sighted short-tailed opossums.bioRxiv : the preprint server for biology · 2026Article
- Simultaneous path-integration recalibration in head direction and place cells.Current biology : CB · 2026Article
- Months-long stability of the head-direction system.Nature · 2026Article
- Projections from the supragenual nucleus to the lateral mammillary and dorsal tegmental nuclei.Brain structure & function · 2025Article
- Synchronized path-integration recalibration but distinct landmark-control dynamics in head direction and CA1 place cells.bioRxiv : the preprint server for biology · 2025Article
- Grid cells accurately track movement during path integration-based navigation despite switching reference frames.Nature neuroscience · 2025Article
- Stereo olfaction underlies stable coding of head direction in blind mice.Nature communications · 2025Article
- Article
- Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies.Nature communications · 2024Article
- Altered grid-like coding in early blind people.Nature communications · 2024Article
- Sensory and behavioral modulation of thalamic head-direction cells.Nature neuroscience · 2024Article
- Angular Head Velocity Cells within Brainstem Nuclei Projecting to the Head Direction Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Coregistration of heading to visual cues in retrosplenial cortex.Nature communications · 2023Article
- Attractor and integrator networks in the brain.Nature reviews. Neuroscience · 2022Review
- A Spiking Neural Network Model of Rodent Head Direction Calibrated With Landmark Free Learning.Frontiers in neurorobotics · 2022Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Vision plays a crucial role in instructing the brain's spatial navigation systems. However, little is known about how vision loss affects the neuronal encoding of spatial information. Here, recording from head direction (HD) cells in the anterior dorsal nucleus of the thalamus in mice, we find stable and robust HD tuning in rd1 mice, a model of photoreceptor degeneration, that go blind by approximately one month of age. In contrast, placing sighted animals in darkness significantly impairs HD cell tuning. We find that blind mice use olfactory cues to maintain stable HD tuning and that prior visual experience leads to refined HD cell tuning in blind rd1 adult mice compared to congenitally blind animals. Finally, in the absence of both visual and olfactory cues, the HD attractor network remains intact but the preferred firing direction of HD cells drifts over time. These findings demonstrate flexibility in how the brain uses diverse sensory information to generate a stable directional representation of space.
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