ReviewTrends in neurosciences2022
Consider the pons: bridging the gap on sensory prediction abnormalities in schizophrenia.
Review in Trends in neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Cerebellar stimulation in schizophrenia: A systematic review of the evidence and an overview of the methods.Frontiers in psychiatry · 2022Pooled it
- Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study.Scientific reports · 2026Article
- "Schizophrenia, Consciousness, and the Self" Twenty Years Later: Revisiting the Ipseity-Disturbance Model and the Developmental Nature of Self-Disorder in the Schizophrenia Spectrum.Schizophrenia bulletin · 2025Review
- Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder.Schizophrenia (Heidelberg, Germany) · 2025Article
- Multivariate Association Between Functional Connectivity Gradients and Cognition in Schizophrenia Spectrum Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Divisive attenuation based on noisy sensorimotor predictions accounts for excess variability in self-touch.Journal of neurophysiology · 2025Article
- Linking DNA methylation in brain regions to Alzheimer's disease risk: a Mendelian randomization study.Human molecular genetics · 2025Article
- An upper temporal limit of action-effect integration as reflected by motor adaptation.Psychological research · 2025Article
- Article
- Pons connectivity correlates with neurophysiological and clinical signatures of predictive coding in psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Pons-to-Cerebellum Hypoconnectivity Along the Psychosis Spectrum and Associations With Sensory Prediction and Hallucinations in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (μCAPs).Human brain mapping · 2024Article
- Meeting the multidimensional self: fostering selfhood at the interface of Creative Arts Therapies and neuroscience.Frontiers in psychology · 2024Review
- Aberrant sense of agency induced by delayed prediction signals in schizophrenia: a computational modeling study.Schizophrenia (Heidelberg, Germany) · 2023Article
- Article
- The role of the cerebellum in sequencing and predicting social and non-social events in patients with bipolar disorder.Frontiers in cellular neuroscience · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A shared mechanism across species heralds the arrival of self-generated sensations, helping the brain to anticipate, and therefore distinguish, self-generated from externally generated sensations. In mammals, this sensory prediction mechanism is supported by communication within a cortico-ponto-cerebellar-thalamo-cortical loop. Schizophrenia is associated with impaired sensory prediction as well as abnormal structural and functional connections between nodes in this circuit. Despite the pons' principal role in relaying and processing sensory information passed from the cortex to cerebellum, few studies have examined pons connectivity in schizophrenia. Here, we first briefly describe how the pons contributes to sensory prediction. We then summarize schizophrenia-related abnormalities in the cortico-ponto-cerebellar-thalamo-cortical loop, emphasizing the dearth of research on the pons relative to thalamic and cerebellar connections. We conclude with recommendations for advancing our understanding of how the pons relates to sensory prediction failures in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.