Evidence map›Paper›PMID 36123064›Full record

ArticleBMJ open2022

Protocol of an iterative qualitative study to develop a molecular testing decision aid for shared decision-making in patients with lung cancer after surgery.

Xing Wei, Yangjun Liu, Hongfan Yu, Wei Dai, Ding Yang, Kunpeng Zhang, Jing Sun, Wei Xu, Ruoyan Gong, Qingsong Yu and 9 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05191485 (Shared Decision Making in Patients With Lung Cancer After Surgery:a Molecular Testing Decision Aid Evidence Based Development Study), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05191485 recruitingnot on this mapstarted 2023, after this paper: background citation

Shared Decision Making in Patients With Lung Cancer After Surgery:a Molecular Testing Decision Aid Evidence Based Development Study

Typeobservational_patient_registrySponsorSichuan Cancer Hospital and Research InstituteRan2023 to 2027Enrolled190ConditionsSurgery, Lung AdenocarcinomaArmsQualitative interviews
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xing WeiDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.ORCID 0000-0002-3035-5633
Yangjun LiuDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-3540-5361
Hongfan YuState Key Laboratory of Biomedical Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.ORCID 0000-0003-3167-1491
Wei DaiDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.ORCID 0000-0003-1650-1590
Ding YangDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID 0000-0002-6329-8962
Kunpeng ZhangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.ORCID 0000-0001-9541-7092
Jing SunKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), VIP-II Gastrointestinal Cancer Division of the Department of Medicine, Peking University Cancer Hospital, Beijing, China.ORCID 0000-0002-4345-0293
Wei XuSchool of Public Health, Chongqing Medical University, Chongqing, China.ORCID 0000-0002-7769-9601
Ruoyan GongSchool of Public Health, Chongqing Medical University, Chongqing, China.ORCID 0000-0003-2724-8615
Qingsong YuSchool of Public Health, Chongqing Medical University, Chongqing, China.ORCID 0000-0001-6142-3339
Yang PuSchool of Public Health, Chongqing Medical University, Chongqing, China.ORCID 0000-0002-4358-6203
Yaqin WangDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.ORCID 0000-0003-4373-7435
Jia LiaoDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.ORCID 0000-0002-0385-8032
Yunfei MuDepartment of Thoracic Surgery, Chengdu Third People's Hospital, Chengdu, China.ORCID 0000-0002-7079-9861
Yuanqiang ZhangDepartment of Cardiothoracic Surgery, Zigong First People's Hospital, Zigong, China.ORCID 0000-0002-9034-061X
Wenhong FengDepartment of Thoracic and Cardiovascular Surgery, Jiangyou People's Hospital, Jiangyou, China.ORCID 0000-0003-1173-3624
Qi PanDepartment of Clinical Psychology, Shunde Hospital, Southern Medical University/The First People's Hospital of Shunde, Foshan, China.ORCID 0000-0003-4700-9232
Qiang Li *Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China qshi@cqmu.edu.cn liqiang@sichuancancer.org.ORCID 0000-0003-1841-4132
Qiuling Shi *Center for Cancer Prevention Research, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China qshi@cqmu.edu.cn liqiang@sichuancancer.org.ORCID 0000-0003-0660-3809

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlthough molecular testing is crucial for many patients with lung cancer, the decision to carry out molecular testing is not easy to make in actual clinical scenarios. Using a specific decision aid (DA) to conduct shared decision-making (SDM) may help ameliorate this problem. However, no DA currently exists for lung cancer molecular testing (DA_LCMT). We aim to develop an evidence-based, iteratively refined DA, which may facilitate SDM and improve the quality of SDM. METHODS AND ANALYSIS: After considering the Ottawa Decision Support Framework, International Patient Decision Aid Standards and Food and Drug Administration guidance about methods to identify what is important to patients, semistructured interviews with qualitative research methods will be used to generate the decision-making needs of patients with lung cancer diagnosed with lung adenocarcinoma by intraoperative frozen pathological sections. Input will be provided by patients and other stakeholders, including thoracic surgeons, nurses, hospital administrators, molecular testing company staff and insurance company staff. Then, a modified Delphi method will be used to develop the DA_LCMT V.1.0 (DA_LCMT 1.0). Structured interviews with qualitative research methods will be used in the cognitive debriefing (alpha tests) and field testing (beta tests) to revise and improve the DA_LCMT from version 1.0 to the final version, version 3.0. Descriptive statistics will be used to summarise the baseline characteristics of the patients and other stakeholders. Qualitative data will be analysed using the three steps of grounded theory: generate a codebook, update the codebook and create a comprehensive list of related items. ETHICS AND DISSEMINATION: Ethics Committee for Medical Research and New Medical Technology of Sichuan Cancer Hospital approved this study. This protocol is based on the latest version 1.0, dated 31 October 2021. The study was also approved by the Ethics Committees of The Third People's Hospital of Chengdu, Zigong First People's Hospital and Jiangyou People's Hospital. The results of this study will be presented at medical conferences and published in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT05191485.

Indexed as

Decision MakingLung NeoplasmsDecision Support TechniquesHumansMolecular Diagnostic TechniquesQualitative ResearchUnited Statesmolecular aspectsoncogenesrespiratory tract tumoursthoracic surgery

Identifiers

PMID36123064
PMCPMC9486363

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.