Evidence map›Paper›PMID 36122963›Full record

ReviewJournal for immunotherapy of cancer2022

MRI techniques for immunotherapy monitoring.

Doreen Lau, Pippa G Corrie, Ferdia A Gallagher

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Journal for immunotherapy of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. [Pseudoprogression after start of immunotherapy].Radiologie (Heidelberg, Germany) · 2026
    Review
  7. Article
  8. Tumor-Targeting TACS omega · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Correlation of KJournal for immunotherapy of cancer · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Doreen LauCentre for Immuno-Oncology, University of Oxford, Oxford, UK doreen.lau@ndm.ox.ac.uk fag1000@cam.ac.uk.ORCID 0000-0002-7623-2401
Pippa G CorrieDepartment of Oncology, Addenbrooke's Hospital, Cambridge, UK.ORCID 0000-0003-4875-7021
Ferdia A GallagherDepartment of Radiology, University of Cambridge, Cambridge, UK doreen.lau@ndm.ox.ac.uk fag1000@cam.ac.uk.ORCID 0000-0003-4784-5230
Addenbrooke's Hospital · GBUniversity of Cambridge · GBUniversity of Oxford · GB

Funding

Cancer Research UK 16628Cancer Research UK 27150
6 · The paper itself

Abstract

MRI is a widely available clinical tool for cancer diagnosis and treatment monitoring. MRI provides excellent soft tissue imaging, using a wide range of contrast mechanisms, and can non-invasively detect tissue metabolites. These approaches can be used to distinguish cancer from normal tissues, to stratify tumor aggressiveness, and to identify changes within both the tumor and its microenvironment in response to therapy. In this review, the role of MRI in immunotherapy monitoring will be discussed and how it could be utilized in the future to address some of the unique clinical questions that arise from immunotherapy. For example, MRI could play a role in identifying pseudoprogression, mixed response, T cell infiltration, cell tracking, and some of the characteristic immune-related adverse events associated with these agents. The factors to be considered when developing MRI imaging biomarkers for immunotherapy will be reviewed. Finally, the advantages and limitations of each approach will be discussed, as well as the challenges for future clinical translation into routine clinical care. Given the increasing use of immunotherapy in a wide range of cancers and the ability of MRI to detect the microstructural and functional changes associated with successful response to immunotherapy, the technique has great potential for more widespread and routine use in the future for these applications.

Indexed as

ImmunotherapyNeoplasmsCell TrackingHumansImmunologic FactorsMagnetic Resonance ImagingTumor MicroenvironmentImmunologic FactorsImmunologic TechniquesImmunotherapyTumor Biomarkers

Identifiers

PMID36122963
PMCPMC9486399
OpenAlexW4296293073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.