Evidence map›Paper›PMID 36122931›Full record

ReviewCold Spring Harbor perspectives in medicine2023

Biological Restraints on Indefinite Survival.

Jan Vijg, Steven N Austad

Open access · greenAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Geroscience and Its Promise.Cold Spring Harbor perspectives in medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jan VijgDepartment of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA jan.vijg@einsteinmed.edu austad@uab.edu.
Steven N AustadProtective Life Endowed Chair in Healthy Aging Research, Department of Biology, The University of Alabama at Birmingham, Birmingham, Alabama 35233, USA jan.vijg@einsteinmed.edu austad@uab.edu.
Albert Einstein College of Medicine · USUniversity of Alabama at Birmingham · US

Funding

THE IMPACT OF CELLULAR DEFENSE ON THE ROLE OF Ku80 IN GENOME MAINTENANCE AND LONGP01AG017242 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI VIJG, JAN · 1999 to 2023
$46.1M
The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Vadim N. Gladyshev · 2014 to 2026
$36.9M
Validation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI NIR J BARZILAI, Paul D. Robbins · 2017 to 2026
$24.5M
Sex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jianhua Zhang · 2015 to 2026
$11.3M
Einstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VIJG, JAN · 2010 to 2024
$10.8M
Cross-Validation of Genome Integrity Assays in Primary Human CellsU01ES029519 · NIEHS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SPIVACK, SIMON D, VIJG, JAN · 2018 to 2022
$3.6M
(PQB4) Age-cancer interplay of genome and epi-genome in human lungR01CA180126 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI AUTON, ADAM, SPIVACK, SIMON D · 2013 to 2016
$2.8M
Integrative, age-related changes in genome and epigenome in human lung in relation to smokingU01HL145560 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SPIVACK, SIMON D, VIJG, JAN · 2019 to 2022
$2.6M
A sex difference approach to evaluating resilience as a predictor of healthspan in miceR01AG057434 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AUSTAD, STEVEN N., CARTER, CHRISTY SHAWN · 2017 to 2021
$1.5M
A Four Core Genotype (FCG) Approach to Investigating Sex Differences in Health and LongevityR21AG058811 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AUSTAD, STEVEN N. · 2018 to 2019
$408k
NCI NIH HHS R01 CA180126NHLBI NIH HHS U01 HL145560NIA NIH HHS P01 AG017242NIA NIH HHS P01 AG047200NIA NIH HHS P30 AG038072NIA NIH HHS P30 AG050886NIA NIH HHS R01 AG057434NIA NIH HHS R21 AG058811NIA NIH HHS U19 AG056278NIEHS NIH HHS U01 ES029519
6 · The paper itself

Abstract

Multiple observations that organismal life span can be extended by nutritional, genetic, or pharmacological intervention has raised the prospect of transforming medicine with the goal of slowing, stopping, or even reversing age-associated disease and maintaining or restoring health and resilience in the increasing numbers of elderly across the world. The potential for such an enterprise is supported in theory by plant and animal models of negligible senescence, most notably the small, freshwater organism

Indexed as

AgingBowhead WhaleAgedAnimalsBiological EvolutionHumansLongevity

Identifiers

PMID36122931
PMCPMC10071417
OpenAlexW4296380799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.