ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2022
Clinical, Experimental, and Computational Validation of a New Doppler-Based Index for Coarctation Severity Assessment.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Geometric Determinants of Post-stenotic Energetics in Coarctation of Aorta: Linking Centerline Morphology to Downstream Energy Loss.Annals of biomedical engineering · 2026Article
- Severity and duration-dependent aortic stiffening in a rabbit coarctation model identifies constitutive material parameters as promising regional biomarkers for hypertension progression.Scientific reports · 2026Article
- A Novel Diastolic Doppler Index Less Affected by Aortic Arch Anomalies Co-existing with Coarctation.Pediatric cardiology · 2025Article
- Computational model of coarctation of the aorta in rabbits suggests persistent ascending aortic remodeling post-correction.Biomechanics and modeling in mechanobiology · 2025Article
- Coarctation Duration and Severity Predict Risk of Hypertension Precursors in a Preclinical Model and Hypertensive Status Among Patients.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Coarctation duration and severity predict risk of hypertension precursors in a preclinical model and hypertensive status among patients.medRxiv : the preprint server for health sciences · 2024Article
- Consistency of the continuous flow pressure gradient despite aortic arch anomalies co-existing with coarctation.medRxiv : the preprint server for health sciences · 2023Article
- Aortic Remodeling Kinetics in Response to Coarctation-Induced Mechanical Perturbations.Biomedicines · 2023Article
- Temporal evolution of mechanical stimuli from vascular remodeling in response to the severity and duration of aortic coarctation in a preclinical model.Scientific reports · 2023Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLong-term morbidity including hypertension often persists in coarctation patients despite current guidelines. Coarctation severity can be invasively assessed via peak-to-peak catheter pressure gradient (PPCG), which is estimated noninvasively via simplified Bernoulli equation and conventionally reported as peak instantaneous Doppler gradient (PIDG). However, underlying simplifications of the equation limit diagnostic accuracy. We studied the diagnostic performance of a new Doppler-based diastolic index called the continuous flow pressure gradient (CFPG) versus conventional indices in assessing coarctation severity.
methodsIn a rabbit model mimicking human aortic coarctation, temporal blood pressure waveforms revealed the diastolic instantaneous pressure gradients and spectral Doppler features impacted by coarctation severity. We therefore hypothesized that CFPG provides superior correlation with coarctation gradients measured invasively. PIDG and CFPG were quantified using color flow echocardiography in humans and rabbits with discrete coarctations. Results were compared with PPCG in rabbits (n = 34) and arm-leg systolic gradients (n = 25) in humans via 1-way analysis of variance, Pearson's correlation, linear regression, and Bland-Altman analysis.
resultsA threshold of CFPG ≥ 4.6 mm Hg was identified via the Youden index as representative of PPCG ≥ 20 mm Hg (the current guideline value for coarctation intervention) in rabbits, while a CFPG ≥1.0 mm Hg represented an arm-leg systolic gradient ≥20 mm Hg in humans. Accuracy measures revealed superior correlation of CFPG (R
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