ArticleProceedings of the National Academy of Sciences of the United States of America2022
Human cone elongation responses can be explained by photoactivated cone opsin and membrane swelling and osmotic response to phosphate produced by RGS9-catalyzed GTPase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Who cites it
33 citing papers in PubMed, 37 citations in OpenAlex.
- Spatio-temporal optical coherence imaging and tomography forJournal of biomedical optics · 2026Review
- Split-Spectrum Amplitude-Decorrelation Optoretinography Detects Impaired Photoreceptor Function in Age-Related Macular Degeneration.Ophthalmology science · 2026Article
- In vivo elastography of the human retina using light-evoked intrinsic actuation.bioRxiv : the preprint server for biology · 2026Article
- Optoretinography in R9AP-bradyopsia reveals the essential role of G-protein signaling in the human cone elongation response.bioRxiv : the preprint server for biology · 2026Article
- Dark adaptation of cone photoreceptor responses is revealed by optoretinography.bioRxiv : the preprint server for biology · 2026Article
- Phase-based optoretinographic measurements of cones with a raster-scanning adaptive optics OCT are highly repeatable.Biomedical optics express · 2026Article
- Evaluating Human Rod Photoreceptor Function Using Pixelwise Intensity-Based Optoretinography.Translational vision science & technology · 2026Article
- ƒ(Cell): Software for Reproducible Analysis of Optoretinograms.Translational vision science & technology · 2026Article
- Functional OCT with parfocal retinal stimulation enables multi-site optoretinography under a single dark adaptation.Biomedical optics express · 2026Article
- Optoretinography reveals rapid rod photoreceptor movement upon rhodopsin activation.Light, science & applications · 2026Article
- Combined Mouse Retinal Optoretinography/Electroretinography System to Study Light-Evoked Responses in Animal Models of Retinal Degeneration.Investigative ophthalmology & visual science · 2026Article
- Structure of human green cone opsin yields insights into mechanisms underlying the rapid decay of its active, signaling state.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Influence of retinal eccentricity, color blindness, and age on optoretinography measured with AOSLO.Biomedical optics express · 2025Article
- Recent Developments in Photoreceptor Optoretinography and Progress Toward Clinical Use.Translational vision science & technology · 2025Review
- Interferometric imaging of the reversible rhodopsin dynamics in the living rat eye.Nature communications · 2025Article
- On the physiological processes underlying optoretinography [Invited].Biomedical optics express · 2025Review
- Longitudinal Changes in Optoretinography Provide an Early and Sensitive Biomarker of Outer Retinal Disease.American journal of ophthalmology · 2025Article
- Optoretinography with actively stabilized adaptive optics optical coherence tomography.Biomedical optics express · 2025Article
- Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli.Science advances · 2025Article
- Whole retina light-evoked optoretinography (ORG) under different retina hydration levels: modeling of Bruch's membrane ORGs.Biomedical optics express · 2025Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Human cone outer segment (COS) length changes in response to stimuli bleaching up to 99% of L- and M-cone opsins were measured with high resolution, phase-resolved optical coherence tomography (OCT). Responses comprised a fast phase (∼5 ms), during which COSs shrink, and two slower phases (1.5 s), during which COSs elongate. The slower components saturated in amplitude (∼425 nm) and initial rate (∼3 nm ms
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.