Evidence map›Paper›PMID 36122240›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors.

Vikas Arige, Lara E Terry, Larry E Wagner, Sundeep Malik, Mariah R Baker, Guizhen Fan, Suresh K Joseph, Irina I Serysheva, David I Yule

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Pacemaking in the lymphatic system.The Journal of physiology · 2026
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  3. Conformational landscape and clustering of human type 2 IPbioRxiv : the preprint server for biology · 2026
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  5. From IP3RPEP6 Inhibition of IPCellular and molecular life sciences : CMLS · 2025
    Review
  6. Article
  7. Tuft cells in the intestine, immunity and beyond.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  8. Article
  9. The ion channels of endomembranes.Physiological reviews · 2024
    Review
  10. Article
  11. Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  12. Distribution of P2Y and P2X purinergic receptor expression within the intestine.American journal of physiology. Gastrointestinal and liver physiology · 2024
    Article
  13. Article
  14. Article
  15. Structural titration reveals CaNature communications · 2023
    Article
  16. Article
  17. Understanding IPCell calcium · 2023
    Review
  18. Viewing CaCell calcium · 2023
    Article
  19. Article
  20. Location, location, and activation of a channel by calcium.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Vikas ArigeDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642.ORCID 0000-0002-0589-1880
Lara E TerryDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642.ORCID 0000-0002-0200-4334
Larry E WagnerDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642.ORCID 0000-0002-5631-8697
Sundeep MalikDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642.
Mariah R BakerDepartment of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.ORCID 0000-0002-1613-9387
Guizhen FanDepartment of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.
Suresh K JosephDepartment of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0002-2991-3458
Irina I SeryshevaDepartment of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.ORCID 0000-0001-6266-3422
David I YuleDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642.ORCID 0000-0002-6743-0668
University of Rochester · USImaging Center · USThomas Jefferson University · US

Funding

[Ca2+]i and Secretory Dynamics in Parotid Acinar CellsR01DE014756 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2002 to 2026
$9.9M
An experimental/computational approach for understanding salivary fluid secretionR01DE019245 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2008 to 2026
$9.7M
Structure-Function Studies Of IP3R ChannelsR01GM072804 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SERYSHEVA, IRINA I · 2005 to 2023
$4.8M
Regulation of inositol trisphosphate receptorsR01GM132611 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI JOSEPH, SURESH K · 2020 to 2023
$1.3M
NIDCR NIH HHS R01 DE019245NIGMS NIH HHS R01 GM072804NIGMS NIH HHS R01 GM132611
6 · The paper itself

Abstract

Inositol 1,4,5-trisphosphate receptors (IP

Indexed as

CalciumInositol 1,4,5-Trisphosphate ReceptorsRyanodine Receptor Calcium Release ChannelAdenosine TriphosphateAmino Acids, BasicBinding SitesInositol 1,4,5-TrisphosphateAdenosine TriphosphateAmino Acids, BasicCalciumInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsRyanodine Receptor Calcium Release Channelcalcium signalinginositol 1,4,5 triphosphate receptorion channel regulation

Identifiers

PMID36122240
PMCPMC9522344
OpenAlexW4296458937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.