Evidence map›Paper›PMID 36122217›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Brain dysfunction during warming is linked to oxygen limitation in larval zebrafish.

Anna H Andreassen, Petter Hall, Pouya Khatibzadeh, Fredrik Jutfelt, Florence Kermen

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 81 citations in OpenAlex.

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  15. Characterization of darter (Conservation physiology · 2025
    Article
  16. Resilience of circuits to environmental challenge.Current opinion in neurobiology · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Respiratory acidosis and OConservation physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Anna H AndreassenDepartment of Biology, Faculty of Natural Sciences, Norwegian University of Science and Technology, Trondheim, 7491 Norway.ORCID 0000-0003-0208-1812
Petter HallDepartment of Biology, Faculty of Natural Sciences, Norwegian University of Science and Technology, Trondheim, 7491 Norway.ORCID 0000-0002-4661-4767
Pouya KhatibzadehDepartment of Biology, Faculty of Natural Sciences, Norwegian University of Science and Technology, Trondheim, 7491 Norway.ORCID 0000-0002-8397-9159
Fredrik JutfeltDepartment of Biology, Faculty of Natural Sciences, Norwegian University of Science and Technology, Trondheim, 7491 Norway.ORCID 0000-0001-9838-3991
Florence KermenDepartment of Biology, Faculty of Natural Sciences, Norwegian University of Science and Technology, Trondheim, 7491 Norway.
Norwegian University of Science and Technology · NOUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the physiological mechanisms that limit animal thermal tolerance is crucial in predicting how animals will respond to increasingly severe heat waves. Despite their importance for understanding climate change impacts, these mechanisms underlying the upper thermal tolerance limits of animals are largely unknown. It has been hypothesized that the upper thermal tolerance in fish is limited by the thermal tolerance of the brain and is ultimately caused by a global brain depolarization. In this study, we developed methods for measuring the upper thermal limit (CT

Indexed as

BrainOxygenThermotoleranceZebrafishAnimalsCalciumLarvaWaterCalciumOxygenWatercalcium imagingCTmaxheat stressspreading depolarizationthermal limit

Identifiers

PMID36122217
PMCPMC9522358
OpenAlexW4296297482

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.