ArticlePLoS genetics2022
Genome sequencing and comparative analysis of Wolbachia strain wAlbA reveals Wolbachia-associated plasmids are common.
Article in PLoS genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Calibrating and documenting host-switching and evolution of incompatibility loci for two closely related Wolbachia clades.Genetics · 2026Article
- Host-Associated Occurrence of Wolbachia in Natural Populations of the Pyriform Scale Protopulvinaria pyriformis (Cockerell, 1894) in Moroccan Orchards.Neotropical entomology · 2026Article
- Extensive mobilome dynamics in a widespread endosymbiont: long read metagenomics reveal dimeric plasmids and highly fragmented prophages in Wolbachia from Culex pipiens.Research square · 2026Article
- Calibrating and documenting host-switching and evolution of incompatibility loci for two closely relatedbioRxiv : the preprint server for biology · 2026Article
- Genome assembly and protein structure modeling reveal key molecular features of divergentMicrobiology spectrum · 2026Article
- A co-speciation dilemma and a lifestyle transition with genomic consequences in Wolbachia of Neotropical Drosophila.BMC genomics · 2025Article
- Deubiquitylases and nucleases in bacterial symbiont-induced cytoplasmic incompatibility.Biochemical Society transactions · 2025Review
- Diversity and spread of cytoplasmic incompatibility genes among maternally inherited symbionts.PLoS genetics · 2025Article
- Comprehensive review of Wolbachia research (1936-2024): Global landscape, mapping progress and themes.Parasite epidemiology and control · 2025Review
- Suppression of cytoplasmic incompatibility in the leaf-mining flyRoyal Society open science · 2025Article
- Overview and Prospects of DNA Sequence Visualization.International journal of molecular sciences · 2025Review
- Review
- Review
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- Direct sequencing of insect symbionts via nanopore adaptive sampling.Current opinion in insect science · 2024Review
- Wolbachia: Advancing into a Second Century.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Transinfected Wolbachia strains induce a complex of cytoplasmic incompatibility phenotypes: Roles of CI factor genes.Environmental microbiology reports · 2023Article
- Metagenomics of culture isolates and insect tissue illuminate the evolution ofMicrobial genomics · 2023Article
- pWCP is a widely distributed and highly conserved Wolbachia plasmid in Culex pipiens and Culex quinquefasciatus mosquitoes worldwide.ISME communications · 2023Article
- Genome-wide detection ofFrontiers in cellular and infection microbiology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Wolbachia are widespread maternally-transmitted bacteria of arthropods that often spread by manipulating their host's reproduction through cytoplasmic incompatibility (CI). Their invasive potential is currently being harnessed in field trials aiming to control mosquito-borne diseases. Wolbachia genomes commonly harbour prophage regions encoding the cif genes which confer their ability to induce CI. Recently, a plasmid-like element was discovered in wPip, a Wolbachia strain infecting Culex mosquitoes; however, it is unclear how common such extra-chromosomal elements are in Wolbachia. Here we sequenced the complete genome of wAlbA, a strain of the symbiont found in Aedes albopictus, after eliminating the co-infecting and higher density wAlbB strain that previously made sequencing of wAlbA challenging. We show that wAlbA is associated with two new plasmids and identified additional Wolbachia plasmids and related chromosomal islands in over 20% of publicly available Wolbachia genome datasets. These plasmids encode a variety of accessory genes, including several phage-like DNA packaging genes as well as genes potentially contributing to host-symbiont interactions. In particular, we recovered divergent homologues of the cif genes in both Wolbachia- and Rickettsia-associated plasmids. Our results indicate that plasmids are common in Wolbachia and raise fundamental questions around their role in symbiosis. In addition, our comparative analysis provides useful information for the future development of genetic tools to manipulate and study Wolbachia symbionts.
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