Evidence map›Paper›PMID 36121616›Full record

SynthesisReproductive sciences (Thousand Oaks, Calif.)2023

The Effect of Endometrial Scratch on Pregnancy Rate in Women with Previous Intrauterine Insemination Failure: a Systematic Review and Meta-analysis of Randomized Controlled Trials.

Saeed Baradwan, Majed Saeed Alshahrani, Rayan AlSghan, Waleed H Alkhamis, Saud Abdullah Alsharif, Gharam Abdulrahman Alanazi, Rania Mahfouz Abdelwahed, Eman A Alkholy, Mahmoud Fouad, Mohamed Saleh and 7 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Reproductive sciences (Thousand Oaks, Calif.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 2 countries.

Saeed BaradwanDepartment of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Majed Saeed AlshahraniDepartment of Obstetrics and Gynecology, Faculty of Medicine, Najran University, Najran, Saudi Arabia.
Rayan AlSghanDepartment of Obstetrics and Gynecology, Maternity and Children Hospital, AlKharj, Saudi Arabia.
Waleed H AlkhamisDepartment of Obstetrics and Gynecology, College of Medicine, King Saud University, King Saud University Medical City, Riyadh, Saudi Arabia.
Saud Abdullah AlsharifCollege of Medicine, Prince Sattam Bin Abdulaziz University, AlKharj, Saudi Arabia.
Gharam Abdulrahman AlanaziCollege of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Rania Mahfouz AbdelwahedDepartment of Obstetrics and Gynecology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Eman A AlkholyDepartment of Obstetrics and Gynecology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Mahmoud FouadDepartment of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Mohamed SalehDepartment of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Manal G AbdelatiDepartment of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Hosam Eldin Mohamad AlazazyDepartment of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohamed A ElsenityDepartment of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ahmed Mohamed AbdelhakimKasralainy, Faculty of Medicine, Cairo University, Cairo, Egypt. ahmed.m.rohei@students.kasralainy.edu.eg.ORCID 0000-0001-9579-8366
Mohamed Abdelsattar MohamedDepartment of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Ahmed M AbbasDepartment of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Eman M MojahedDepartment of Obstetrics and Gynecology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Al-Azhar University · EGAin Shams University · EGAssiut University · EGCairo University · EGFayoum University · EGKing Faisal Specialist Hospital & Research Centre · SAKing Saud Medical City · SAMaternity and Children's Hospital · SANajran University · SAPrince Sattam Bin Abdulaziz University · SAPrincess Nourah bint Abdulrahman University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to evaluate the impact of endometrial scratch on the pregnancy rate among women with previous failed intrauterine insemination (IUI). A systematic search was done in PubMed, Cochrane Library, Scopus, and ISI web of science from inception to November 2021. We selected randomized clinical trials (RCTs) that compared endometrial scratch in the intervention group versus placebo or no intervention in the control group among infertile women with previous failure of IUI regarding different pregnancy outcomes. Revman software was utilized for performing our meta-analysis. Our main outcomes were biochemical pregnancy, clinical pregnancy, and live birth rates. Five RCTs met our inclusion criteria with a total number of 989 patients. We found endometrial scratch significantly improved the biochemical and clinical pregnancy rates in comparison with the control group among women with previous IUI failure (p < 0.001). Moreover, the live birth rate was significantly increased among the endometrial scratch group (RR = 2.00, 95% CI [1.20, 3.34], p = 0.008). In conclusion, endometrial scratch is effective in improving pregnancy outcomes among women with previous IUI failure. More trials are required to confirm our findings.

Indexed as

EndometriumFertilization in VitroFemaleHumansInseminationInsemination, ArtificialLive BirthOvulation InductionPregnancyPregnancy RateRandomized Controlled Trials as TopicEndometrial scratchIntrauterine insemination failureIUI failurePregnancy rate

Identifiers

PMID36121616
OpenAlexW4296285986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.