Evidence map›Paper›PMID 36121587›Full record

ArticleCardiovascular drugs and therapy2024

Direct Oral Anticoagulation Versus Warfarin in Patients with Atrial Fibrillation and Bioprosthetic Heart Valves: a Retrospective, Real-World Cohort Study.

Rachel Eikelboom, Richard P Whitlock, Serena Sibilio, Francis Nguyen, Richard Perez, Jeffrey I Weitz, Emilie Belley-Cote

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In one paragraph

Article in Cardiovascular drugs and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Rachel EikelboomDepartment of Surgery, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada. eikelbr@mcmaster.ca.ORCID 0000-0001-6005-5458
Richard P WhitlockDivision of Cardiac Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Serena SibilioDipartimento Di Cardiochirurgia, Istituto Clinico Sant'Ambrogio, Milan, Lombardy, Italy.
Francis NguyenInstitute for Clinical Evaluative Sciences McMaster, McMaster University, Hamilton, ON, Canada.
Richard PerezInstitute for Clinical Evaluative Sciences McMaster, McMaster University, Hamilton, ON, Canada.
Jeffrey I WeitzDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Emilie Belley-CoteDivision of Cardiology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Institute for Clinical Evaluative Sciences · CAMcMaster University · CAIstituto Clinico Sant'Ambrogio · ITThrombosis and Atherosclerosis Research Institute · CAUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn this retrospective cohort study of consecutive patients with atrial fibrillation and surgical or transcatheter bioprosthetic valve, we compared the efficacy and safety of direct oral anticoagulants with warfarin.

methodsUsing linked health administrative databases housed at the Institute for Clinical Evaluative Sciences, we identified consecutive patients in Ontario (Canada) 65 years of age or older with AF who underwent bioprosthetic valve replacement between 1 April 2012 and 31 March 2017. We created a time-varying Cox model to examine the relationship between the type of anticoagulant and time to thrombotic or bleeding events after adjustment for baseline risk of thrombosis using the CHA

resultsWe identified 2245 eligible patients. The mean age was 79 years, 41% were female, and 39% had transcatheter aortic valve replacement. Risk of death or thrombosis was not different between direct oral anticoagulants and warfarin after adjustment for CHA

conclusionsIn a real-world population of patients with atrial fibrillation and bioprosthetic valve replacement, we found no difference between direct oral anticoagulants and warfarin with regard to the risk of thrombosis or bleeding.

Indexed as

Atrial FibrillationHeart Valve ProsthesisStrokeThrombosisAdministration, OralAgedAnticoagulantsCohort StudiesFemaleHeart ValvesHemorrhageHumansMaleRetrospective StudiesTreatment OutcomeWarfarinAnticoagulantsWarfarinAnti-thrombotic therapyAortic valve replacementBioprosthetic valves

Identifiers

PMID36121587
OpenAlexW4296330756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.