SynthesisJournal of molecular medicine (Berlin, Germany)2022
The serotonin receptor 3E variant is a risk factor for female IBS-D.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of molecular medicine (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Article
- The serotonin-gated 5-HT3 receptor: a tale of functions and structures of a prototypical pentameric ligand-gated ion channel.Acta pharmacologica Sinica · 2026Review
- The Mast Cell-PAR2-TRP Axis: A Convergent Mechanism for Visceral Hypersensitivity Independent of Divergent Motility in IBS.Biomolecules · 2026Review
- Unraveling the Pathophysiology of Irritable Bowel Syndrome: Mechanisms and Insights.International journal of molecular sciences · 2025Review
- Sinisan Alleviates Stress-Induced Intestinal Dysfunction and Depressive-like Behaviors in Mice with Irritable Bowel Syndrome by Enhancing the Intestinal Barrier and Modulating Central 5-Hydroxytryptamine.International journal of molecular sciences · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
55 authors at 20 institutions in 10 countries.
Nikola FritzInstitute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Sabrina BerensDepartment of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany.
Yuanjun DongInstitute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Cristina MartínezInstitute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Stefanie SchmitteckertInstitute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany. Stefanie.Schmitteckert@med.uni-heidelberg.de.
Lesley A HoughtonUniversity of Leeds, St. James's University Hospital, Leeds, UK.
Miriam Goebel-StengelDepartment of Psychosomatic Medicine, University Hospital Tübingen, Tübingen, Germany.
Verena WahlInstitute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Maria KabischInstitute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Germany.
Dorothea GötzeInstitute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Mauro D'AmatoUnit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Tenghao ZhengUnit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Ralph RöthInstitute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Hubert MönnikesMartin-Luther-Hospital, Berlin, Germany.
Jonas TesarzDepartment of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany.
Felicitas EngelDepartment of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany.
Annika GaussDepartment of Gastroenterology, Infectious Diseases and Intoxications, Heidelberg University, Heidelberg, Germany.
Martin RaithelUniversity of Erlangen, Erlangen, Germany.
Viola AndresenIsraelitisches Krankenhaus, Hamburg, Germany.
Jutta KellerIsraelitisches Krankenhaus, Hamburg, Germany.
Thomas FrielingHelios Klinik Krefeld, Krefeld, Germany.
Christian PehlKrankenhaus Vilsbiburg, Vilsbiburg, Germany.
Christoph Stein-ThöringerGerman Cancer Research Center, Heidelberg, Germany.
Gerard ClarkeDepartment of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland.
Paul J KennedyDepartment of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland.
John F CryanDepartment of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland.
Timothy G DinanDepartment of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland.
Eamonn M M QuigleyAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Robin SpillerNottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.
Caroll BeltránGastroenterology Unit, Medicine Department, Hospital Clínico Universidad de Chile, Universidad de Chile, Santiago de Chile, Chile.
Ana María MadridGastroenterology Unit, Medicine Department, Hospital Clínico Universidad de Chile, Universidad de Chile, Santiago de Chile, Chile.
Verónica TorresGastroenterology Unit, Medicine Department, Hospital Clínico Universidad de Chile, Universidad de Chile, Santiago de Chile, Chile.
Emeran A MayerOppenheimer Center for Neurobiology of Stress, University of California, Los Angeles, CA, USA.
Gregory SayukWashington University School of Medicine, St. Louis, MO, USA.
Maria GazouliLaboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
George KaramanolisAcademic Department of Gastroenterology, Medical School, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.
Mariona BustamanteCRG, Centre for Genomic Regulation, Barcelona, Spain.
Xavier EstivilDepartment of Genetics, Microbiology and Statistics, Faculty of Biology, IBUB, Universitat de Barcelona, CIBERER, IRSJD, Barcelona, Spain.
Raquel RabionetDepartment of Genetics, Microbiology and Statistics, Faculty of Biology, IBUB, Universitat de Barcelona, CIBERER, IRSJD, Barcelona, Spain.
Per HoffmannLife and Brain Center, Bonn, Germany.
Markus M NöthenLife and Brain Center, Bonn, Germany.
Stefanie Heilmann-HeimbachLife and Brain Center, Bonn, Germany.
Börge SchmidtInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany.
André FrankeInstitute of Clinical Molecular Biology, Kiel, Germany.
Wolfgang LiebInstitute of Epidemiology, Kiel, Germany.
Wolfgang HerzogDepartment of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany.
Guy BoeckxstaensTARGID, University Hospital Leuven, Louvain, Belgium.
Mira M WoutersTARGID, University Hospital Leuven, Louvain, Belgium.
Magnus SimrénInstitute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Gudrun A RappoldInstitute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Maria VicarioInstitut de Recerca Vall d Hebron, Hospital Vall d Hebron, Passeig de la Vall d Hebron, Barcelona, Spain.
Javier SantosInstitut de Recerca Vall d Hebron, Hospital Vall d Hebron, Passeig de la Vall d Hebron, Barcelona, Spain.
Rainer SchaefertDepartment of Psychosomatic Medicine, Division of Theragnostics, University Hospital Basel, Basel, Switzerland.
Justo Lorenzo-BermejoInstitute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Germany.
Beate NieslerInstitute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0001-7881-6112
Heidelberg University · DEUniversity College Cork · IEHospital Clínico de la Universidad de Chile · CLLife & Brain (Germany) · DECentre for Biomedical Network Research on Rare Diseases · ESIsraelitisches Krankenhaus · DENational and Kapodistrian University of Athens · GRVall d'Hebron Institut de Recerca · ESCentre for Genomic Regulation · ESCornell University · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGerman Cancer Research Center · DEHelios Klinikum Krefeld · DEIkerbasque · ESInstitute of Molecular Biology · DEInstitut für Medizinische Informatik, Biometrie und Epidemiologie · DEKarolinska Institutet · SEKrankenhaus vom Roten Kreuz · DEMartin-Luther-Krankenhaus · DEUniversity of Basel · CH
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT
Indexed as
Irritable Bowel SyndromeFemaleGenotypeHumansMulticenter Studies as TopicReceptors, SerotoninRisk FactorsSerotoninReceptors, SerotoninSerotoninFemalesIBS-DIrritable bowel syndromeSerotonin type 3 receptor
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.